TY - JOUR T1 - Chemotherapy for posttransplant lymphoproliferative disorder: the Israel Penn International Transplant Tumor Registry experience JF - Transplant Proc Y1 - 2005 A1 - Buell,J. F. A1 - Gross,T. G. A1 - Hanaway,M. J. A1 - Trofe,J. A1 - Muthiak,C. A1 - First,M. R. A1 - Alloway,R. R. A1 - Woodle,E. S. KW - Antigens, CD / blood KW - B-Lymphocytes / immunology KW - Female KW - Heart Transplantation / *immunology / mortality KW - Humans KW - Kidney Transplantation / *immunology / mortality KW - Liver Transplantation / *immunology / mortality KW - Lymphoproliferative Disorders / *drug therapy KW - Male KW - Pancreas Transplantation / *immunology / mortality KW - Postoperative Complications / *drug therapy KW - Recurrence KW - Registries KW - Survival Analysis AB - INTRODUCTION: Very little published data exist regarding the results of chemotherapy treatment of posttransplant lymphoproliferative disorder (PTLD). The purpose of the study was to review the Israel Penn International Transplant Tumor Registry experience with PTLD treated with chemotherapy. METHODS: Patients with PTLD who received chemotherapy were identified and data collected regarding demographics, tumor characteristics, recurrence rates, and survival. RESULTS: One hundred ninety three solid organ transplant recipients with PTLD who received chemotherapy were identified. Most patients were male (142:51) and Caucasian (148; 16 AA, 29 unspecified). Most PTLD were B-cell predominant (81%), monoclonal (71), and CD 20+ (60% of patients tested). Organ transplanted included: kidney, 92 (48%); heart, 54 (28%); liver, 30 (16%); pancreas, 8 (4%); and lung, 9 (5%). Median time to presentation posttransplant was 24.5 months (range 0.8 to 226.5 months). Ninety patients received CHOP, 12 ProMACE, 65 other multidrug regimens, and 23 patients received single-agent chemotherapy. Five-year survival for these four regimens were: 24%, 25%, 32%, and 5%. PTLD-specific death rates were 34%, 34%, 40%, and 48%. CONCLUSIONS: Single-agent chemotherapy appears to be inferior to other chemotherapy regimens for PTLD as it is associated with lower survival. VL - 37 CP - 2 N1 - 0041-1345 (Print) Journal Article Multicenter Study ID - 242 ER -