02877nas a2200277   4500008004100000020001400041024001700055245012400072210006900196260029900265300001400564490000700578520175300585653003002338653001302368653002202381653001602403100002002419700002102439700001602460700001802476700002102494700001902515700002002534856004502554       2015                        eng d  a0041-1132  awdn, 041736000aTransfusion-associated Anaplasma phagocytophilum infection in a pregnant patient with thalassemia trait: a case report.0 aTransfusionassociated Anaplasma phagocytophilum infection in a p  a(C) 2015 John Wiley & Sons, Ltdb(1) Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts,(2) Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts,(3) Division of c2015  a719 - 7250 v553 a<p>BACKGROUND: Human granulocytic anaplasmosis (HGA) is an acute nonspecific febrile illness caused by the bacterium Anaplasma phagocytophilum. Although usually transmitted via tick bite, HGA may rarely also be acquired through transfusion. HGA during pregnancy may pose significant gestational risks due to altered maternal immune status and the potential for perinatal transmission., CASE REPORT: A pregnant 34-year-old Massachusetts woman with [beta]-thalassemia trait was diagnosed at 32 weeks of gestation with transfusion-associated HGA (TAHGA) after receiving nine leukoreduced red blood cell transfusions. She was successfully treated with rifampin therapy and gave birth to a healthy child who tested negative for HGA after delivery. An implicated blood donor was subsequently identified through physician collaboration with the regional American Red Cross and Massachusetts Department of Public Health., DISCUSSION: This is the 11th reported case of HGA in pregnancy and is at least the sixth known case in which leukoreduction did not prevent TAHGA. As seen in this case, nonspecific symptomatology of variable onset can impede diagnosis and treatment. This may increase risk of poor outcomes in maternal HGA patients. Cases of TAHGA, although currently uncommon, may increase as the incidence of HGA in certain parts of the country increases., CONCLUSION: Heightened cross-institutional awareness of the potential risk of TAHGA is warranted. Clinicians need to consider transfusion-associated infections when fever occurs in a transfusion recipient. This case provides additional evidence that leukoreduction does not obviate risk of A. phagocytophilum contamination of donated blood components., (C) 2015 John Wiley &amp; Sons, Ltd</p>10aAnaplasma phagocytophilum10apregnant10athalassemia trait10atransfusion1 aShields, Kelsey1 aCumming, Melissa1 aRios, Jorge1 aWong, Michael1 aZwicker, Jeffrey1 aStramer, Susan1 aAlonso, Carolyn  uhttps://notifylibrary.org/reference/4369