03230nas a2200361   4500008004100000020001400041024001700055245020300072210006900275260030400344300001400648490000700662520187100669653002202540653000802562653001302570653002502583653002302608653000902631653001002640653001602650100001402666700001502680700001802695700001702713700001602730700001502746700001502761700001502776700001602791700001602807856004502823       2013                        eng d  a0958-7578  abu7, 930118200aImpact of immunoreactive substances contained in apheresis platelet concentrate on postoperative respiratory function in surgical patients receiving platelet transfusion: a prospective cohort study.0 aImpact of immunoreactive substances contained in apheresis plate  a(C) 1999?2012 John Wiley & Sons, Incb(1) Departments of Anesthesiology, Kyorin University School of Medicine(2) Department of Perioperative Medicine, School of Dentistry, Showa University(3) Research and Development Department, Central Blood Institute, Blood Service Headquarters, Japanese Rec2013  a344 - 3500 v233 aObjectives: To construct an alternative policy for the donor selection of platelet concentrate (PC), a clinical study exploring the features of lung injury following PC administration is needed., Background: Although a male-donor-only policy for plasma products appears to have efficiently reduced transfusion-related acute lung injury (TRALI), this policy may not be applied to PC because of supply shortages., Methods and Materials: We prospectively examined pulmonary function after the transfusion of PC in informed surgical patients treated at a tertiary university hospital in Japan. The contributions of immunoreactive substances contained in the PC to respiratory function after PC transfusion was then statistically examined., Results: Eighty-six patients (56 men, 30 women) were enrolled in the analysis. Fifty-four cases experienced respiratory failure (PaO2/FiO2 <300 mmHg) after transfusion. Five cases were diagnosed as possible TRALI based on permeability pulmonary oedema, while 23 cases were diagnosed as transfusion-associated circulatory overload (TACO) based on chest radiograph findings. A multivariate logistic regression analysis identified the presence of anti-granulocyte antibody as a significant predictor of possible TRALI [P = 0[middle dot]023; odds ratio (OR), 13[middle dot]0; 95% confidence interval (CI), 1[middle dot]4-118[middle dot]3]. Meanwhile, anti-leukocyte antibody class II was identified as a significant independent predictor of TACO (P = 0[middle dot]010; OR, 18[middle dot]4; 95% CI, 2[middle dot]0-170[middle dot]1)., Conclusions: Our data suggest that antibodies contained in PC may contribute to the deterioration of respiratory function after PC transfusion, although the diagnoses of TACO and TRALI may have overlapped among the patients with pulmonary distress in this cohort., (C) 1999?2012 John Wiley & Sons, Inc10aanti-HLA antibody10aLPC10aplatelet10aplatelet concentrate10apulmonary distress10aTACO10aTRALI10atransfusion1 aKanai, R.1 aIijima, T.1 aHashimoto, S.1 aNakazawa, H.1 aOhnishi, H.1 aYorozu, T.1 aOhkawa, R.1 aNojiri, T.1 aShimizu, M.1 aOkazaki, H.  uhttps://notifylibrary.org/reference/4339