02889nas a2200265   4500008004100000020001400041024001900055245011000074210006900184260029800253300001400551490000700565520179800572653002602370653003302396653002702429653002302456653002502479100001602504700001402520700001202534700001602546700001602562856004502578       2014                        eng d  a1398-2273  ad1d, 10088368800aSevere life-threatening Ehrlichia chaffeensis infections transmitted through solid organ transplantation.0 aSevere lifethreatening Ehrlichia chaffeensis infections transmit  a(C) 2014 John Wiley & Sons A/Sb(1)Nephrology, Department of Medicine, Newark Beth Israel Medical Center, Newark, New Jersey, USA(2)Department of Medicine, University of Maryland Medical Center, Baltimore, Maryland, USA(3)Division of Infectious Diseases, Department of Medicine, Institutc2014  a119 - 1240 v163 aBackground. Donor-derived infections from organ transplantation are rare occurrences with preoperative screening practices. Ehrlichia chaffeensis, a tick-borne illness, transmitted through solid organ transplantation has not been reported previously to our knowledge. We present cases of 2 renal allograft recipients who developed severe E. chaffeensis infection after receipt of organs from a common deceased donor., Methods. The 2 renal transplant patients who developed E. chaffeensis infection are reported in case study format with review of the literature., Results. Approximately 3 weeks after renal transplantation, both patients developed an acute febrile illness and rapid clinical decline. Recipient A underwent an extensive infectious workup that revealed positive E. chaffeensis DNA from polymerase chain reaction on peripheral blood. Recipient B's clinical team obtained acute and convalescent antibody titers for E. chaffeensis, which demonstrated acute infection. Recipients A and B were treated with doxycycline and tigecycline, respectively, with clinical cure., Conclusions. These cases demonstrate that tick-borne pathogens, such as E. chaffeensis, can be transmitted through renal transplantation. E. chaffeensis can be associated with excessive morbidity and mortality, commonly owing to delay in diagnosis and poor response to non-tetracycline antibiotics. In populations with endemic tick-borne illness, donors should be questioned about tick exposure, and appropriate antibiotics can be administered if indicated., S.H. Sachdev, V. Joshi, E.R. Cox, A. Amoroso, S. Palekar. Severe life-threatening Ehrlichia chaffeensis infections transmitted through solid organ transplantation. Transpl Infect Dis 2014: 16: 119-124. All rights reserved, (C) 2014 John Wiley & Sons A/S10aEhrlichia chaffeensis10ahuman monocytic ehrlichiosis10asolid organ transplant10atick-borne illness10atransplant infection1 aSachdev, S.1 aJoshi, V.1 aCox, E.1 aAmoroso, A.1 aPalekar, S.  uhttps://notifylibrary.org/reference/4260