02466nas a2200301   4500008004100000020001400041024001700055245009800072210006900170260014900239300001300388490000700401520138400408653004101792653003801833653004401871653003101915653003301946653001501979653003701994653001102031653001102042100001902053700001702072700001502089700001502104856004502119       2000                        eng d  a0041-1132  awdn, 041736000aAn acute hemolytic transfusion reaction due to anti-IH in a patient with sickle cell disease.0 aacute hemolytic transfusion reaction due to antiIH in a patient   aUNITED STATESbCampbell,S A. Transfusion Medicine Division, Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.c2000  a828 - 310 v403 aBACKGROUND: A hemolytic transfusion reaction (HTR) due to anti-IH is reported in a patient with sickle cell disease (SCD)., CASE REPORT: An 18-year-old woman with SCD and a complete phenotype on file had been identified as group B-positive with negative antibody-screening tests and had received 1 unit of packed RBCs. Ten days later, she was readmitted in painful crisis with a Hb of 4.2 g per dL. Antibody-screening tests and panel cells were positive at all test phases with a negative autocontrol, which suggested alloantibodies. Phenotypically matched group O RBCs were issued emergently. After the transfusion of 100 mL, the patient had an HTR with chills, fever, and tachycardia and laboratory findings of hemoglobinemia, hemoglobinuria, and negative DATs. A high-titer, IgM anti-IH with a high thermal amplitude (reactive with group O, but not group B RBCs at 37 degrees C) was identified. Autologous RBCs appeared to have normal I antigen expression, but less H antigen than pooled group B RBCs. She was given group B RBCs, uneventfully, by use of a blood warmer., CONCLUSIONS: This is a rare case of anti-IH as the cause of a HTR, as a serologic problem that may be seen in SCD, and as an autoantibody that may mimic an alloantibody. Ironically, this HTR resulted from the effort to provide phenotypically matched RBCs, which necessitated the selection of group O RBCs.10a*Anemia, Sickle Cell/im [Immunology]10a*Anemia, Sickle Cell/th [Therapy]10a*Blood Transfusion/ae [Adverse Effects]10a*Hemolysis/im [Immunology]10a*Isoantigens/im [Immunology]10aAdolescent10aBlood Grouping and Crossmatching10aFemale10aHumans1 aCampbell, S, A1 aShirey, R, S1 aKing, K, E1 aNess, P, M  uhttps://notifylibrary.org/reference/4233