03037nas a2200325   4500008004100000020001400041024001700055245016400072210006900236260029900305520176800604653001702372653001002389653000902399653001002408653001502418653001602433100001902449700001702468700001802485700001902503700002202522700002102544700002002565700002002585700001502605700002602620700002002646856004502666       2015                        eng d  a0902-4441  aerf, 870398500aPrevalence and distribution of iron overload in patients with transfusion-dependent anemias differs across geographic regions: results from the CORDELIA study.0 aPrevalence and distribution of iron overload in patients with tr  a(C) 2015 John Wiley & Sons, Ltdb(1) Ege University Hospital, Izmir, Turkey(2) University College London, London, UK(3) University of Turin, Turin, Italy(4) Ain Shams University, Cairo, Egypt(5) Cairo University, Cairo, Egypt(6) Cukurova University Medical Faculty, Adana, Turkey(7) Sirirc20153 aObjectives: The randomized comparison of deferasirox to deferoxamine for myocardial iron removal in patients with transfusion-dependent anemias (CORDELIA) gave the opportunity to assess relative prevalence and body distribution of iron overload in screened patients., Methods: Patients aged >=10 yr with transfusion-dependent anemias from 11 countries were screened. Data were summarized descriptively, overall and across regions., Results: Among 925 patients (99.1% with [beta]-thalassemia major; 98.5% receiving prior chelation; mean age 19.2 yr), 36.7% had myocardial iron overload (myocardial T2* <=20 ms), 12.1% had low left ventricular ejection fraction. Liver iron concentration (LIC) (mean 25.8 mg Fe/g dw) and serum ferritin (median 3702 ng/mL) were high. Fewer patients in the Middle East (ME; 28.5%) had myocardial T2* <=20 ms vs. patients in the West (45.9%) and Far East (FE, 40.9%). Patients in the West had highest myocardial iron burden, but lowest LIC (26.9% with LIC <7 mg Fe/g dw) and serum ferritin. Among patients with normal myocardial iron, a higher proportion of patients from the ME and FE had LIC >=15 than <7 mg Fe/g dw (ME, 56.7% vs. 17.2%; FE, 78.6% vs. 7.8%, respectively), a trend which was less evident in the West (44.6% vs. 33.9%, respectively). Transfusion and chelation practices differed between regions., Conclusions: Evidence of substantial myocardial and liver iron burden across regions revealed a need for optimization of effective, convenient iron chelation regimens. Significant regional variation exists in myocardial and liver iron loading that are not well explained; improved understanding of factors contributing to differences in body iron distribution may be of clinical benefit., (C) 2015 John Wiley & Sons, Ltd10adistribution10aHeart10airon10aLiver10aPrevalence10athalassemia1 aAydinok, Yesim1 aPorter, John1 aPiga, Antonio1 aElalfy, Mohsen1 aEl-Beshlawy, Amal1 aKilinc, Yurdanur1 aViprakasit, Vip1 aYesilipek, Akif1 aHabr, Dany1 aQuebe-Fehling, Erhard1 aPennell, Dudley  uhttps://notifylibrary.org/reference/4184