02524nas a2200289   4500008004100000020001400041024001200055245011400067210006900181260031200250300001400562490000700576520132600583653002201909653002501931653004001956100002001996700001902016700002102035700002202056700002202078700002302100700002002123700002202143700002402165856004502189       2007                        eng d  a1386-6346  a971180100aPersistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma.0 aPersistent infection of hepatitis E virus transmitted by blood t  aCopyright (C) 2007 Blackwell Publishing Ltd.b(1)Division of Gastroenterology and Hepatology, Advanced Medical Research Center, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan(2)Department of Immunology and Microbiology, Advanced Medical Research Center, Nihon University School of Medic2007  a113 - 1200 v373 aAim: With advent of reverse-transcription (RT)/polymerase chain reaction (PCR) for detection of the hepatitis E viral genome, we carried out retrospective examinations., Methods: Serum samples collected from 68 patients diagnosed as viral hepatitis with unknown etiology were tested for viral markers of hepatitis virus., Results: Two of them were found positive for hepatitis E viral RNA. While the clinical course of one patient (patient 1) was typical as acute hepatitis E, another patient (patient 2) was persistently infected with HEV. Patient 2 was infected with the virus via blood transfusion during chemotherapy against T-cell lymphoma. The entire viral genome from the donor was identical with that from the serum of patient 2 obtained on day 170 after the transfusion of the implicated red blood cell (RBC) product, confirming the transmission of HEV by transfusion. The patient remained negative for anti-HEV antibodies for the follow-up period of six months, probably due to immune suppression by lymphoma and chemotherapy., Conclusion: We report here an unusual case of long-term HEV infection in a patient with T-cell lymphoma. Persistent infection with HEV was probably due to the absence of anti-HEV antibodies, which was caused by lymphoma and chemotherapy., Copyright (C) 2007 Blackwell Publishing Ltd.10aHepatitis E virus10apersistent infection10atransfusion-transmitted hepatitis E1 aTamura, Akinori1 aShimizu, Yohko1 aTanaka, Torahiko1 aKuroda, Kazumichi1 aArakawa, Yasuyuki1 aTakahashi, Kazuaki1 aMishiro, Shunji1 aShimizu, Kazufumi1 aMoriyama, Mitsuhiko  uhttps://notifylibrary.org/reference/4073