03133nas a2200349   4500008004100000020001400041024001700055245014000072210006900212260002400281300001200305490000700317520194600324653003302270653003502303653003502338653004902373653004802422653000902470653003902479653001102518653004602529653005202575653001102627653000902638653001602647653001702663653003202680653001802712100000802730856004502738       2011                        eng d  a1545-861X  ane8, 780242900aPotential transmission of viral hepatitis through use of stored blood vessels as conduits in organ transplantation--Pennsylvania, 2009.0 aPotential transmission of viral hepatitis through use of stored   aUnited Statesc2011  a172 - 40 v603 aSolid organ transplantation sometimes requires the use of blood vessels from a deceased donor as conduits to connect transplanted organ vessels to recipient vessels. Vessels not immediately used are sometimes stored for later use, including vessels collected from hepatitis B virus (HBV) and hepatitis C virus (HCV) seropositive donors; HBV and HCV seropositive vessels can be stored for use in seropositive recipients. In May 2009, HCV was transmitted when a transplant facility inadvertently used a blood vessel conduit from an HCV-seropositive donor in a seronegative recipient. In November 2009, a second transplant facility, the University of Pittsburgh Medical Center (UPMC), identified two cases of potential hepatitis virus transmission from vessel conduits. In December 2009, CDC was asked to assist the local health department in conducting an investigation at UPMC. This report summarizes the results of that investigation, which determined that, although neither recipient of the vessel conduits at UPMC contracted hepatitis, these represented "near miss" incidents in which transmission could have occurred. The storage of vessels from hepatitis-seropositive donors at UPMC and its affiliated Department of Veterans Affairs (VA) hospital was not necessary; vessels from seropositive donors were infrequently used because adequate supplies of vessels from seronegative donors were available. UPMC's prohibition of the storage of vessels from hepatitis-seropositive donors has removed a documented risk factor for viral transmission while not substantially affecting the transplant centers' vessel conduit supply. Evaluation of available national data supports this prohibition. Therefore, CDC recommends that transplant centers discontinue the practice of storing vessel from donors with markers for viral hepatitis, including HBV surface antigen (HBsAg), HCV antibody (anti-HCV), and HBV or HCV detectable by nucleic acid tests.10a*Blood Vessels/vi [Virology]10a*Hepatitis B/tm [Transmission]10a*Hepatitis C/tm [Transmission]10a*Kidney Transplantation/ae [Adverse Effects]10a*Liver Transplantation/ae [Adverse Effects]10aAged10aBlood Vessels/tr [Transplantation]10aFemale10aHepacivirus/ip [Isolation & Purification]10aHepatitis B virus/ip [Isolation & Purification]10aHumans10aMale10aMiddle Aged10aPennsylvania10aTissue Banks/st [Standards]10aTissue Donors1 aCDC  uhttps://notifylibrary.org/reference/4049