04014nas a2200301   4500008004100000020001400041024001200055245008200067210006900149260046900218300001600687490000800703520272700711653001503438653002103453653001703474653002203491653001903513653001703532100001503549700001203564700002503576700001303601700001903614700002203633700001203655856004503667       2008                        eng d  a0098-7484  a750116000aAdverse Reactions to Allogeneic Whole Blood Donation by 16- and 17-Year-Olds.0 aAdverse Reactions to Allogeneic Whole Blood Donation by 16 and 1  aCopyright 2008 by the American Medical Association.  All Rights Reserved.  Applicable FARS/DFARS Restrictions Apply to Government Use.  American Medical Association, 515 N. State St, Chicago, IL 60610.bBiomedical Services, Medical Office, National Headquarters, American Red Cross, Washington, DC (Drs Eder and Benjamin and Ms Dy); Emory University, School of Medicine, Atlanta, Georgia, and Southern Region, American Red Cross, Douglasville, Georgia (Dr Hic2008  a2279 - 22860 v2993 aContext: Donations by minors (16- and 17-year-olds) now account for approximately 8% of the whole blood collected by the American Red Cross, but young age and first-time donation status are known to be independent risk factors for donation-related complications., Objective: To evaluate adverse reactions to allogeneic whole blood donation by 16- and 17-year-olds compared with older donors in American Red Cross blood centers., Design, Setting, and Participants: Prospective documentation of adverse events among 16- and 17-year-old donors using standardized collection protocols, definitions, and reporting methods in 2006. Data were from 9 American Red Cross blood centers that routinely collect from 16- and 17-year-olds, a population that provides 80% of its donations at high school blood drives., Main Outcome Measures: Rate of systemic (syncopal-type) and phlebotomy-related donor complications per 10 000 collections., Results: In 2006, 9 American Red Cross regions collected 145 678 whole blood donations from 16- and 17-year-olds, 113 307 from 18- and 19-year-olds, and 1 517 460 from donors aged 20 years or older. Complications were recorded in 15 632 (10.7%), 9359 (8.3%), and 42 987 (2.8%) donations in each corresponding age group. In a multivariate logistic regression model, young age had the strongest association with complications (odds ratio [OR], 3.05; 95% confidence interval [CI], 2.52-3.69; P < .001), followed by first-time donation status (OR, 2.63; 95% CI, 2.24-3.09; P < .001) and female sex (OR, 1.87; 95% CI, 1.62-2.16; P < .001). Infrequent but medically relevant complications, in particular physical injury from syncope-related falls, were significantly more likely in 16- and 17-year-old donors (86 events; 5.9/10 000 collections) compared with 18- and 19-year-old donors (27 events; 2.4/10 000 collections; OR, 2.48; 95% CI, 1.61-3.82) or adults aged 20 years or older (62 events; 0.4/10 000 collections; OR, 14.46; 95% CI, 10.43-20.04). Sixteen-year-old donors who experienced even a minor complication were less likely to return to donate within 12 months than 16-year-olds who experienced uncomplicated donations (52% vs 73% return rate; OR, 0.40; 95% CI, 0.36-0.44)., Conclusions: A higher incidence of donation-related complications and injury occurs among 16- and 17-year-old blood donors compared with older donors. The increasing dependence on recruiting and retaining young blood donors requires a committed approach to donor safety, especially at high school blood drives., Copyright 2008 by the American Medical Association.  All Rights Reserved.  Applicable FARS/DFARS Restrictions Apply to Government Use.  American Medical Association, 515 N. State St, Chicago, IL 60610.10aAdolescent10aadverse reaction10aBlood Donors10aBlood Transfusion10aPatient Safety10aRisk Factors1 aEder, Anne1 aMD, PhD1 aHillyer, Christopher1 aDy, Beth1 aNotari, Edward1 aBenjamin, Richard1 aMD, PhD  uhttps://notifylibrary.org/reference/4012