02436nas a2200277   4500008004100000022004700041245007500088210006900163250001000232260000800242300001300250490000600263520140700269653004601676653003301722653003701755653007401792653004501866653001101911653005101922653007301973653003802046100001502084700001402099856004502113       2007                        eng d  a1745-8331 (Electronic) 1745-8323 (Linking)00aParvovirus-B19-associated complications in renal transplant recipients0 aParvovirusB19associated complications in renal transplant recipi  a39352  cOct  a540 - 500 v33 aParvovirus B19 is a common human pathogen, causing erythema infectiosum in children, hydrops fetalis in pregnant women, and transient aplastic crisis in patients with chronic hemolytic anemia. Immunosuppressed patients can fail to mount an effective immune response to B19, resulting in prolonged or persistent viremia. Renal transplant recipients can develop symptomatic B19 infections as a result of primary infection acquired via the usual respiratory route or via the transplanted organ, or because of reactivation of latent or persistent viral infection. The most common manifestations of B19 infection in immunosuppressed patients are pure red cell aplasia and other cytopenias. Thus, this diagnosis should be considered in transplant recipients with unexplained anemia and reticulocytopenia or pancytopenia. Collapsing glomerulopathy and thrombotic microangiopathy have been reported in association with B19 infection in renal transplant recipients, but a causal relationship has not been definitively established. Prompt diagnosis of B19 infection in the renal transplant recipient requires a high index of suspicion and careful selection of diagnostic tests, which include serologies and polymerase chain reaction. Most patients benefit from intravenous immunoglobulin therapy and/or alteration or reduction of immunosuppressive therapy. Conservative therapy might be sufficient in some cases.10a*Kidney Transplantation / adverse effects10a*Postoperative Complications10aDisease Transmission, Infectious10aErythema Infectiosum / complications / diagnosis / etiology / therapy10aHerpesviridae Infections / complications10aHumans10aImmunoglobulins, Intravenous / therapeutic use10aImmunosuppressive Agents / administration & dosage / adverse effects10aRed-Cell Aplasia, Pure / virology1 aWaldman, M1 aKopp, J B  uhttps://notifylibrary.org/reference/1599