01980nas a2200253   4500008004100000022004700041245004000088210004000128250001000168260000800178300001300186490000600199520129700205653002101502653001201523653002601535653001801561653001101579653002201590653002401612653003201636100001301668856004501681       2008                        eng d  a1573-6814 (Electronic) 1389-9333 (Linking)00aHeat resistance of allograft tissue0 aHeat resistance of allograft tissue  a39522  cDec  a259 - 660 v93 aLyophilized allograft musculoskeletal tissue is generally intended to be stored at "ambient" or "room" temperature, and usually is kept in climate controlled indoor storage areas. However, there is a question of what temperature extremes tissue may see, especially during transportation, in that these extremes may exceed even the limits of "ambient" conditions. Temperatures may become quite hot, but only for a few hours and only during daytime. Damage from high temperatures, if it occurs, is expected to be evident by damage to the collagen component of bone, soft tissue, and demineralized bone, as well as to the growth factors contained in demineralized bone. If damage is significant, then temperature monitoring requirements for lyophilized allograft tissue might be necessary. To answer this question, a literature review was carried out to look at the short-term temperature resistance of collagen and demineralized bone. Both collagen and the growth factors in demineralized bone show remarkable short term tolerance to elevated temperatures in the dry state, and it was concluded that temperature excursions of 50 degrees C or less, lasting for a few days or less, would not cause any significant deterioration. This means that temperature monitoring also should not be required.10a*Hot Temperature10aAnimals10aCollagen / metabolism10aFreeze Drying10aHumans10aOrgan Specificity10aOxidation-Reduction10aTransplantation, Homologous1 aShimp, L  uhttps://notifylibrary.org/reference/1400