01919nas a2200241   4500008003900000245006400039210006400103300001300167490000600180520114000186653004501326653001101371653001101382653004801393653000901441653006201450653000901512653001501521653004501536653003901581100001201620856004501632       1987                          d00aNeoplastic consequences of transplantation and chemotherapy0 aNeoplastic consequences of transplantation and chemotherapy  a149 - 570 v13 aAn increased incidence of certain neoplasms occurs in immunodeficiency states. The incidence of cancer in organ transplant patients is approximately 4%. The predominant tumors are lymphomas, carcinomas of the skin and lips, carcinomas of the vulva/perineum, in situ carcinomas of the uterine cervix, and Kaposi sarcoma (KS). Tumors appear a relatively short time after transplantation. Unusual features of the lymphomas are the high incidence of non-Hodgkin lymphomas, frequent involvement of extranodal sites, and marked predilection for the brain. Skin cancers present unusual features: predominance of squamous cell carcinomas, young age of the patients, and a high incidence of multiple tumors. Cancers of the vulva/perineum occur at a younger age than in the general population and may be preceded by condyloma acuminatum or herpes genitalis. Lymphomas, leukemias, and skin cancers are increased in nontransplant patients who receive immunosuppressive therapy for nonmalignant diseases. Second tumors that develop in cancer patients, after treatment with cytotoxic therapy, are mainly leukemias, lymphomas, and bladder carcinomas.10aAntineoplastic Agents / *adverse effects10aFemale10aHumans10aImmunosuppressive Agents / *adverse effects10aMale10aNeoplasms / chemically induced / epidemiology / *etiology10aOhio10aRegistries10aResearch Support, U.S. Gov't, Non-P.H.S.10aTransplantation / *adverse effects1 aPenn, I  uhttps://notifylibrary.org/reference/1202