01622nas a2200205   4500008003900000245011900039210006900158300001300227490000700240520098900247100001401236700001401250700001801264700001401282700001701296700002101313700002201334700001601356856004401372       2002                          d00aStem cell mobilisation with 16 microg/kg vs 10 microg/kg of G-CSF for allogeneic transplantation in healthy donors0 aStem cell mobilisation with 16 microgkg vs 10 microgkg of GCSF f  a727 - 300 v293 aWe compared two doses of recombinant human granulocyte-stimulating factor (G-CSF) for stem cell mobilisation in 90 healthy donors for allogeneic stem cell transplantation in a retrospective analysis. Group I (n = 46) received 10 microg/kg G-CSF (filgrastim) given as 5 microg/kg twice daily, and group II (n = 44) received 16 microg/kg, given as 8 microg/kg twice daily with a 12-h interval. The groups were well-balanced for age and body-weight. G-CSF application was performed on an out-patient basis, and leukapheresis was started in all donors on day 5. The most frequent side-effects of G-CSF were grade I/II, bone pain, headache and fatigue in both groups, whereas grade III of bone pain, headache and fatigue occurred in the 2 x 8 microg/kg group only. One serious non-fatal event with non-traumatic spleen rupture occurred in the 2 x 5 microg/kg group. The CD34(+)cell count in the first apheresis of all donors was 5.1 x 10(6)/kg donor weight (range, 1.5-19.3). The CD34(+) !1 aKroger, N1 aRenges, H1 aSonnenberg, S1 aKruger, W1 aGutensohn, K1 aDielschneider, T1 aCortes-Dericks, L1 aZander, A R  uhttps://notifylibrary.org/reference/838