01779nas a2200229   4500008003900000245010900039210006900148260000800217300001400225490000700239520111500246100001401361700001401375700001801389700001701407700001501424700001601439700001901455700001401474700001701488856004401505       2002                          d00aDonation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints0 aDonation of stem cells from blood or bone marrow results of a ra  cMar  a479 - 4860 v293 aBiological consequences and physical complaints were compared for donors randomly assigned either to blood stem cell (BSC) or bone marrow (BM) donation. In the period 1994-1999, 61 consecutive donors were included. The BSC donors were given G-CSF 10 mug/kg s.c., daily during 5 days before the first leukapheresis. Nineteen donors had one leukapheresis, 10 required two and one donor needed three leukaphereses in order to reach the target cell number of 2 X 10(6) CD34(+) cells/kg bw of the recipient. A median platelet nadir of 102 X 10(9)/1 was reached shortly after the last leukapheresis. Three weeks post harvest, 17 of 30 BSC donors had a mild leukopenia. Six had a leukopenia lasting more than a year before returning to normal values. Both groups were monitored prospectively through a standardised questionnaire completed by the donors. BSC donation was significantly less burdensome than BM donation and was preferred by the donors. The short-term risks of BSC mobilisation and harvest seem negligible. The potential long-term effects of G-CSF are unresolved and the donors must be followed closely.1 aHeldal, D1 aBrinch, L1 aTjonnfjord, G1 aSolheim, B G1 aEgeland, T1 aGadeholt, G1 aAlbrechtsen, D1 aAamodt, G1 aEvensen, S A  uhttps://notifylibrary.org/reference/659