02944nas a2200361   4500008004100000022004200041245012600083210006900209250001000278260000800288300001300296490000800309520162800317653002901945653003301974653000902007653001902016653005202035653004502087653005702132653005402189653001102243653001602254653001502270653003302285653004502318653001702363653001802380653003302398100001602431700001902447856011602466       2005                        eng d  a0002-9394 (Print) 0002-9394 (Linking)00aEye-banking risk factors for fungal endophthalmitis compared with bacterial endophthalmitis after corneal transplantation0 aEyebanking risk factors for fungal endophthalmitis compared with  a38448  cApr  a685 - 900 v1393 aPURPOSE: To track the relative frequency and explore possible risk factors of fungal compared with bacterial endophthalmitis after corneal transplantation. DESIGN: Case-comparison study nested in a surveillance registry. METHODS: We examined, among recipients who underwent surgery from January 1991 through December 2003, demographic and eye-banking characteristics of postkeratoplasty endophthalmitis cases that were reported to the Eye Bank Association of America by US eye banks. Potential predictors of fungal compared with bacterial endophthalmitis were examined using multiple logistic regression. RESULTS: Of 234 reported cases of postkeratoplasty endophthalmitis reported by US eye bank, 46 cases (19.7%) were fungal, and 130 cases (55.6%) were bacterial. Concordant cultures of the residual donor corneoscleral rim or preservation medium occurred significantly more often with fungal than bacterial endophthalmitis (P = .009). After the introduction of Optisol-GS, the odds of bacterial relative to fungal endophthalmitis decreased by 77% (95% confidence interval, 44% - 91%). After adjustment for the preservation method and other eye-banking variables, the odds of fungal endophthalmitis was 3.4 (95% confidence interval, 1.6 - 7.4) times that of bacterial endophthalmitis, when donor corneal preservation was 4 days or longer. CONCLUSIONS: The frequency of postkeratoplasty bacterial endophthalmitis compared with fungal endophthalmitis fell after widespread use of a corneal preservation medium supplemented with gentamicin and streptomycin. Further improvements in corneal preservation procedures are needed.10a*Corneal Transplantation10a*Postoperative Complications10aAged10aCause of Death10aEndophthalmitis / *epidemiology / *microbiology10aEye Banks / *statistics & numerical data10aEye Infections, Bacterial / *epidemiology / etiology10aEye Infections, Fungal / *epidemiology / etiology10aHumans10aMiddle Aged10aOdds Ratio10aOrgan Preservation / methods10aRegistries / statistics & numerical data10aRisk Factors10aTissue Donors10aUnited States / epidemiology1 aHassan, S S1 aWilhelmus, K R  uinternal-pdf://Hassan - Eye banking risk factors fungal-2476677120/Hassan - Eye banking risk factors fungal.pdf