02324nas a2200289   4500008004100000022004200041245003900083210003900122250001000161260000800171300001200179490000700191520126200198653002901460653001901489653004201508653008301550653002601633653005801659653005401717653001101771653003201782653001801814653005901832100001701891856012601908       1998                        eng d  a0277-3740 (Print) 0277-3740 (Linking)00aSerologic testing of cornea donors0 aSerologic testing of cornea donors  a35885  cMar  a123 - 80 v173 aPURPOSE: To review the current requirements and rationale for serologic testing of cornea donors and to provide guidelines for dealing with results of nonrequired tests. METHODS: Eye Bank Association of America (EBAA) and Food and Drug Administration (FDA) regulations are examined with respect to current knowledge of the risk of donor-to-host transmission of systemic infectious diseases via corneal transplantation. RESULTS: Negative screening tests are required for human immunodeficiency virus (HIV) 1 and 2, hepatitis B surface antigen (HBsAg), and hepatitis C virus (HCV) before release of tissue for transplantation. Other tests reported by organ-procurement organizations commonly include hepatitis B core antibody (anti-HBc), syphilis, cytomegalovirus (CMV), and human T-lymphotropic virus (HTLV) I and II. No systemic infectious-disease transmission from donor corneas supplied by EBAA-member eye banks has occurred in the last 12 years, a period during which >400,000 corneas were provided for transplantation. CONCLUSION: EBAA donor-screening requirements, including serologic testing, have resulted in an excellent safety record. Requirements for serologic testing should continue to be regularly reviewed as new information becomes available.10a*Corneal Transplantation10a*Tissue Donors10acontrol / statistics & numerical data10aDisease Transmission, Infectious / legislation & jurisprudence / *prevention &10aEye Banks / standards10aEye Infections, Bacterial / diagnosis / *transmission10aEye Infections, Viral / diagnosis / *transmission10aHumans10aSerologic Tests / standards10aUnited States10aUnited States Food and Drug Administration / standards1 aGlasser, D B  uinternal-pdf://Glasser - Serologic Testing of corneal donors-1412973313/Glasser - Serologic Testing of corneal donors.pdf