02839nas a2200277   4500008004100000022004200041245012700083210006900210250001000279260001200289300001300301490000600314520186800320653003402188653001902222653003102241653006002272653003502332653001702367653001102384653002702395653006102422653001802483100001602501856004402517       1995                        eng d  a0963-6897 (Print) 0963-6897 (Linking)00aInfectious disease transmission through cell, tissue, and organ transplantation: reducing the risk through donor selection0 aInfectious disease transmission through cell tissue and organ tr  a34943  cSep-Oct  a455 - 770 v43 aThe incidence of cell transplant-transmitted infection is unknown and can only be inferred from prospective studies--that have not yet been performed and reported. The possibility of donor-to-recipient disease transmission through cell transplant therapy can be considered by reviewing the risk associated with other transplanted tissues and organs. Viral, bacterial, and fungal infections have been transmitted via transplantation of organs, tissue allografts such as bone, skin, cornea, and heart valves, and cell such as islets, hematopoietic stem cells, and semen. Several types of protozoan and worm parasites have been transferred via organ transplants. Bone allografts have transmitted hepatitis, tuberculosis, and human immunodeficiency virus (HIV-1). Corneas have transmitted rabies, Creutzfeldt-Jakob disease (CJD), hepatitis B (HBV), cytomegalovirus (CMV), herpes simplex virus (HSV), bacteria, and fungi. Heart valves have been implicated in transmitting tuberculosis and hepatitis B. HIV-1 and CMV seroconversion has been reported in patients receiving skin from seropositive donors. CJD has been transmitted by dura and pericardium transplants. Over the past several years, improvements in donor screening criteria, such as excluding potential donors with infection and those with behaviors risky for HIV-1 and hepatitis infection, and introduction of new donor blood tests have greatly reduced the risk of HIV-1 and hepatitis and may have nearly eliminated the risk of tuberculosis and CJD. Prior to use, many tissues are exposed to antibiotics, disinfectants, and sterilants, which further reduce or remove the risk of transmitted disease. Because organs, cells, and some tissue grafts cannot be subjected to sterilization steps, the risk of infectious disease transmission remains and thorough donor screening and testing is especially important.10a*Communicable Disease Control10a*Tissue Donors10ajurisprudence / *standards10aOrgan Transplantation / adverse effects / legislation &10aQuality Assurance, Health Care10aRisk Factors10aSafety10aSocial Control, Formal10aTissue Transplantation / adverse effects / legislation &10aUnited States1 aEastlund, T  uhttps://notifylibrary.org/reference/466