02156nas a2200277   4500008004100000022004200041245005700083210005600140250001000196260000800206300001200214490000700226520130000233653002501533653002301558653001201581653002201593653007001615653001101685653005701696653002801753653001801781653002001799100001501819856004401834       1996                        eng d  a0899-823X (Print) 0899-823X (Linking)00aHow to limit the spread of Creutzfeldt-Jakob disease0 aHow to limit the spread of CreutzfeldtJakob disease  a35278  cAug  a521 - 80 v173 aTransmissible spongiform encephalopathies are rare lethal diseases induced in humans and animals by unconventional agents called transmissible spongiform encephalopathy agents (TSEAs), virions, or prions. Several cases of iatrogenic Creutzfeldt-Jakob disease (CJD) have been reported in the literature after neurosurgery, treatment with pituitary-derived hormones, corneal grafting, and use of dura mater lyophilisates. In a given infected individual, TSEA-associated infectiousness depends on the nature of the organ: the central nervous system has the highest infectiousness, spleen and lymph nodes a medium infectiousness, and organs such as bone, skin, or skeletal muscles do not harbor any detectable infectiousness in experimental models. Transmissible spongiform encephalopathy/prions have unconventional properties; in particular, they resist almost all the chemical and physical processes that inactivate conventional viruses. Therefore, prevention of CJD agent transmission must be taken into account in daily hospital practice. Efficient sterilization procedures should be determined. In tissue and blood donation, donors with a neurologic history must be excluded, and patients treated with pituitary-derived hormones should be considered potentially infected with TSEA and excluded.10a*Biological Products10a*Infection Control10aAnimals10aBlood Transfusion10aCreutzfeldt-Jakob Syndrome / *prevention & control / transmission10aHumans10aPrion Diseases / prevention & control / transmission10aPrions / *pathogenicity10aSterilization10aTransplantation1 aDormont, D  uhttps://notifylibrary.org/reference/452