01992nas a2200253   4500008003900000245005900039210005900098260001100157300003400168490000700202520128900209653001901498653003301517653001101550653002401561653001701585100001301602700001401615700001401629700002001643700001501663700001601678856004401694       2000                          d00aOrgan donors with primary central nervous system tumor0 aOrgan donors with primary central nervous system tumor  cJul 15  a244 - 8; - discussion - 251-20 v703 aPatients with primary central nervous system (CNS) tumor have been accepted for organ donation because these tumors very rarely spread outside the CNS. However several case reports of CNS tumor transferral with organ transplantation recently challenged this attitude. Some risk factors for extraneural spread of CNS tumors have been determined, but the absence of risk factors does not exclude the possibility of metastases. To our knowledge, 13 cases of CNS tumor transferral with organ transplantation (one heart, three livers, eight kidneys, one kidney/pancreas) have been reported in the literature. Even if no prospective evaluation of the CNS tumor transmission risk with transplantation has been undergone, this risk may be estimated between a little more than 0% and 3% from retrospective series. The authors consider that patients with CNS tumor should be accepted as donors as long as the risk of dying on the waiting lists is significantly higher than the tumor transferral risk. Therefore the authors would have no restriction for transplanting organs from donors with benign or low-grade CNS tumor. For high-grade tumors, the authors would consider these donors as "marginal donors," and balance the risk of tumor transmission with the medical condition of the recipient.10a*Tissue Donors10aBrain Neoplasms / *pathology10aHumans10aNeoplasm Metastasis10aRisk Factors1 aDetry, O1 aHonore, P1 aHans, M F1 aDelbouille, M H1 aJacquet, N1 aMeurisse, M  uhttps://notifylibrary.org/reference/436