01852nas a2200193   4500008004100000022002200041245010100063210006900164250001000233260000800243300001300251490000600264520126600270100001501536700001801551700001301569700001401582856006201596       2007                        eng d  a1177-5467 (Print)00aThe relationship of graft survival and herpes simplex virus latency in recipient corneal buttons0 arelationship of graft survival and herpes simplex virus latency   a39234  cJun  a127 - 310 v13 aPURPOSE: To demonstrate relationship between herpes simplex virus (HSV) corneal latency and graft survival. METHODS: Prospective case control study. 28 recipient corneal buttons and donor cornea-scleral remnants were examined for HSV DNA with polymerase chain reaction (PCR). None of the recipient had a history of HSV infection. Serum samples of graft recipients were analyzed for the presence of anti-HSV IgG and IgM with enzyme-linked immunosorbent assay technique. All corneas were free of stromal scarring or epithelial defect before sampling and had an endothelial cell density of >2000 cells/mm(2). RESULTS: In twenty three patients (82%) anti-HSV IgG was detected in serum. In none of the recipients anti-HSV IgM was positive. HSV DNA was positive in six out of twenty eight (21%) of the recipient corneal buttons and none of the donor cornea-scleral remnants. In eighteen-months follow-up period three out of six (50%) HSV DNA positive and one out of twenty-two (4.5%) HSV DNA negative patients experienced late endothelial failure that was statistically significantly different (p = 0.022). CONCLUSION: Even without a history of HSV keratitis, presence of latent HSV virus in recipient cornea is an important risk factor for subsequent graft survival.1 aAydemir, O1 aTurkcuoglu, P1 aBulut, Y1 aKalkan, A  uinternal-pdf://Aydemir - HSV-4185884929/Aydemir - HSV.pdf