02475nas a2200277   4500008004100000022001400041245012300055210006900178260000800247300001400255490000700269520165200276653000901928653001101937653001101948653002701959653003301986653003902019653000902058653001802067653001602085653002702101653001802128100000802146856004302154       2008                        eng d  a1545-861X00aBrief report: Lymphocytic choriomeningitis virus transmitted through solid organ transplantation--Massachusetts, 2008.0 aBrief report Lymphocytic choriomeningitis virus transmitted thro  cJul  a799 - 8010 v573 a<p>Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne arenavirus found worldwide. House mice (Mus musculus) are the natural reservoir, but LCMV also can infect other wild, pet, and laboratory rodents (e.g., rats, mice, guinea pigs, and hamsters). Humans can be infected through exposure to rodent excreta. Person-to-person transmission has occurred only through maternal-fetal transmission and solid organ transplantation. LCMV infection in humans can be asymptomatic or cause a spectrum of illness ranging from isolated fever to meningitis and encephalitis. Overall case fatality is &lt;1%. Fetal infections can result in congenital abnormalities or death. Immunosuppressed patients, such as organ transplant recipients, can develop fatal hemorrhagic fever-like disease. Transmission of LCMV and an LCMV-like arenavirus via organ transplantation has been documented in three previous clusters. Of 11 recipients described in those clusters, 10 died of multisystem organ failure, with LCMV-associated hepatitis as a prominent feature. The surviving patient was treated with ribavirin (an antiviral with in vitro activity against LCMV) and reduction of immunosuppressive therapy. On April 15, 2008, an organ procurement organization (OPO) notified CDC of severe illness in two kidney transplant recipients from a common donor; at the time of notification, one of the recipients had died. Samples from the donor and both recipients were tested at CDC; on April 22, test results revealed evidence of acute LCMV infection in the donor and both recipients. This report summarizes the results of the subsequent public health investigation.</p>
10aAged10aFemale10aHumans10aKidney Transplantation10aLymphocytic Choriomeningitis10aLymphocytic choriomeningitis virus10aMale10aMassachusetts10aMiddle Aged10aPublic Health Practice10aTissue Donors1 aCDC  uhttps://notifylibrary.org/reference/28