01776nas a2200193   4500008003900000245011600039210006900155260000800224300000700232490000700239520122300246100001301469700001001482700001101492700001001503700001201513700001201525856004501537       2017                          d00aMalignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor0 aMalignant rhabdoid tumor in the renal allograft of an adult tran  cDec  a860 v123 aBackground: Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and lethal tumor primarily affecting the kidney of infants and young children. MRT has not been reported in the renal allograft of an adult recipient after kidney transplantation.
Case presentation: In this report, a 47-year-old woman who received a kidney transplantation from an infant donor and developed a mass in the transplanted kidney is presented. Pathological examinations revealed a malignant tumor with rhabdoid cells morphologically and the loss of INI1 expression immunohistochemically. The diagnosis of malignant rhabdoid tumor in the transplanted kidney was made. We confirmed that donor-to-recipient malignancy transmission was the cause of MRT in the transplanted kidney by fluorescence in situ hybridization (FISH) and short tandem repeat (STR) analysis.
Conclusion: To our knowledge, this is the first case of MRT in an adult renal allograft recipient. This report highlights the importance of the criteria for selection of donors to screen possible malignant tumors transmission.1 aXiong, J1 aSu, T1 aZhu, P1 aAo, Q1 aRuan, Q1 aWang, G  uhttps://notifylibrary.org/reference/4934