01939nas a2200157   4500008003900000245017200039210006900211260000800280490000700288520138600295100001601681700001201697700001301709700001401722856004501736       2016                          d00aSevere Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation After Only the First Administration of Granulocyte-Colony Stimulating Factor0 aSevere Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic  cNov0 v433 aBackground: Granulocyte-colony stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells (PBSCs) in healthy donors. A few reports have shown that some healthy donors developed acute respiratory distress syndrome or capillary leak syndrome after more than several rounds of G-CSF administration or leukapheresis.

Case report: We report the case of a healthy donor for allogeneic stem cell transplantation who developed severe hypoxemia 1 h after only the first administration of G-CSF. The donor was administered 10 μg/kg G-CSF (lenograstim) subcutaneously for PBSC mobilization. 1 h after the first administration of G-CSF, the donor suddenly presented with dry cough and dyspnea. The oxygen saturation by pulse oximetry (SpO2) in the room air was 88%. An electrocardiogram and chest radiography revealed no abnormalities. We excluded other causes of severe hypoxemia and diagnosed the donor with hypoxemia due to G-CSF administration, which was subsequently terminated. The donor was administered 2 l/min oxygen via a nasal cannula and 100 mg hydrocortisone intravenously. He subsequently recovered, and SpO2 in the room air returned to 98% 10 h after hypoxemia.

Conclusion: These respiratory symptoms might be related to anaphylactoid or hypersensitivity reaction. The donors should be observed for at least 1 h after the first administration of G-CSF.1 aYamamoto, K1 aDoki, N1 aSenoo, Y1 aNajima, Y  uhttps://notifylibrary.org/reference/4898