02188nas a2200265   4500008003900000245015700039210006900196260000800265300001100273490000700284520140100291100001301692700002001705700001601725700001401741700001601755700001701771700001401788700001501802700001501817700001301832700001401845700001801859856004501877       2018                          d00aPlasmodium falciparum infection transmitted by transfusion: A cause of hemophagocytic syndrome after bone marrow tranplantation in a non-endemic country0 aPlasmodium falciparum infection transmitted by transfusion A cau  cJun  ae128870 v203 aA 27-year-old man with severe aplastic anemia underwent bone marrow transplantation from his HLA identical brother in July 2016. Conditioning included ATGAM 30 mg/kg for 3 days and Cyclophosphamide 50 mg/kg for 4 days. The patient received several platelet and red blood cell transfusions before and after the conditioning. The patient received broad spectrum antibiotics and caspofungin because persistant febrile neutropenia without bacteriological or mycological documentation. Hemophagocytic syndrome was diagnosed on day +12. Steroids at 1 mg/kg were started on day +12. Fever resolved the same day but resumed 3 days later associated to intravascular hemolysis with no schizocytes on blood smears and negative DAT. Thick blood film smears performed on day +26 revealed Plasmodium falciparum parasites (parasitemia = 20%). Except the level of parasitemia, there were no signs of gravity. Quinine was started on day 26 at a loading dose of 15 mg/kg followed by 8 mg/kg three times a day for 20 doses. Fever vanished after 2 days. Parasitemia cleared in 3 days and remained negative thereafter. Investigations revealed that the patient was transfused by a red cell unit harvested in a voluntary donor native of a malaria endemic country. PCR for P. falciparum performed in this donor in the frame of investigations was positive. The patient is alive with a normal blood count 1 year after BMT.1 aLadeb, S1 aBen Abdejlil, N1 aFakhfakh, N1 aLakhal, A1 aBelloumi, D1 aBen Hamed, L1 aKallel, A1 aTorjman, L1 aFatimi, El1 aHmida, S1 aKallel, K1 aBen Othman, T  uhttps://notifylibrary.org/reference/4767