01411nas a2200157   4500008003900000245010500039210006900144260000800213300000700221490000700228520092500235100001701160700001301177700001801190856004501208       1995                          d00aSevere anaphylactic reaction to bovine serum albumin at the first attempt of artificial insemination0 aSevere anaphylactic reaction to bovine serum albumin at the firs  cFeb  a790 v503 aA 33-year-old woman without history of previous atopic diseases or drug allergies developed a severe anaphylactic reaction with asthma, vomiting, itching, generalized urticaria, and angioedema during artificial insemination with her husband's sperm. The sperm-processing medium contained bovine serum albumin (BSA). Skin prick test and RAST demonstrated an IgE-mediated hypersensitivity to BSA as well as a polyvalent atopic sensitization to pollens, animal danders, cow's milk, beef, pork, and mutton. SDS-PAGE studies indicated serum albumin to be the appropriate allergen with a high degree of cross-reactivity between serum albumin from different animal species. Artificial insemination with fluid containing potential allergens can, therefore, represent an unnecessary risk for atopic females, even in the absence of prior clinical symptoms of allergic diseases. Preoperative testing with the medium is recommended.1 aWüthrich, B1 aStern, A1 aJohansson, SG  uhttps://notifylibrary.org/reference/4686