01901nas a2200205   4500008003900000245011700039210006900156260000800225490000700233520127700240100002401517700001501541700001201556700001601568700001501584700001401599700002501613700001201638856004501650       2017                          d00aRed blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report.0 aRed blood cell transfusiontransmitted acute hepatitis E in an im  cFeb0 v573 aBACKGROUND:

Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion-transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma.
STUDY DESIGN AND METHODS:

A 61-year-old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette-Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored.
RESULTS:

Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient's serum sample.
CONCLUSION:

Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.1 aRiveiro-Barciela, M1 aSauleda, S1 aQuer, J1 aSalvador, F1 aGregori, J1 aPirón, M1 aRodríguez-Frías, F1 aButi, M  uhttps://notifylibrary.org/reference/4671