@article {4499,
	title = {Elderly recipients of hepatitis C positive renal allografts can quickly develop liver disease.},
	journal = {The Journal of surgical research// J Surg Res},
	volume = {176},
	year = {2012},
	month = {2012//},
	pages = {629 - 38},
	address = {United States},
	abstract = {Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46\% while the eD-/R- survival was 85\% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.Copyright {\textcopyright} 2012 Elsevier Inc. All rights reserved.},
	keywords = {*Hepatitis C/tm [Transmission], *Kidney Failure, Chronic/su [Surgery], *Kidney Transplantation/ae [Adverse Effects], *Postoperative Complications/vi [Virology], Adult, Age Factors, Aged, Female, Follow-Up Studies, Graft Rejection/dt [Drug Therapy], Graft Rejection/mo [Mortality], Graft Survival, Hepatitis C/mo [Mortality], Humans, Immunosuppressive Agents/tu [Therapeutic Use], Kaplan-Meier Estimate, Kidney Failure, Chronic/mo [Mortality], Male, Middle Aged, Morbidity, Postoperative Complications/mo [Mortality], Tissue Donors, Transplantation, Homologous, Young Adult},
	isbn = {1095-8673},
	author = {Flohr, Tanya R and Bonatti, Hugo and Hranjec, Tjasa and Keith, Doug S and Lobo, Peter I and Kumer, Sean C and Schmitt, Timothy M and Sawyer, Robert G and Pruett, Timothy L and Roberts, John P and Brayman, Kenneth L}
}
