@article {4441,
	title = {Complications of plasma exchange in 71 consecutive patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic-uremic syndrome.},
	journal = {Transfusion},
	volume = {40},
	year = {2000},
	month = {2000},
	pages = {896 - 901},
	publisher = {Rizvi,M A. Hematology-Oncology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA.},
	address = {UNITED STATES},
	abstract = {BACKGROUND: With the increased frequency of diagnosis and improved survival of thrombotic thrombocytopenic purpura-hemolytic-uremic syndrome (TTP-HUS), the morbidity of plasma exchange (PE) treatment has become more important., STUDY DESIGN AND METHODS: Data were prospectively collected on 71 consecutive patients referred to the Oklahoma Blood Institute (OBI) for PE treatment for clinically suspected TTP-HUS from mid-1996 to mid-1999. Complications were defined as major or minor, and distinguished between those related to central venous catheter access or to the plasma., RESULTS: Twenty-one patients (30\%) had 27 major complications, which caused two deaths. The major complications included 2 episodes of hemorrhage after subclavian line insertion (1 death), 1 pneumothorax requiring a chest tube, 12 systemic infections (1 death), 7 episodes of catheter thrombosis requiring removal of the central venous catheter, 2 episodes of venous thrombosis requiring anticoagulant treatment, 2 episodes of hypoxemia and hypotension, and 1 episode of serum sickness. Minor complications occurred in 22 additional patients (31\%). Twenty-eight patients (39\%) had no complications., CONCLUSIONS: The morbidity and mortality of catheter placement and PE are important considerations when PE treatment for clinically suspected TTP-HUS is anticipated.},
	keywords = {*Hemolytic-Uremic Syndrome/th [Therapy], *Plasma Exchange/ae [Adverse Effects], *Purpura, Thrombotic Thrombocytopenic/th [Therapy], Bacteremia/et [Etiology], Catheterization, Central Venous/ae [Adverse Effects], Fungemia/et [Etiology], Humans, Risk Factors},
	isbn = {0041-1132},
	author = {Rizvi, M A and Vesely, S K and George, J N and Chandler, L and Duvall, D and Smith, J W and Gilcher, R O}
}
