@article {4423,
	title = {Risks of hemolysis due to anti-A and anti-B caused by the transfusion of blood or blood components containing ABO-incompatible plasma.},
	journal = {Transfusion},
	volume = {53 Suppl 1},
	year = {2013},
	month = {2013},
	pages = {114S - 123S},
	publisher = {Berseus,Olle. Department of Transfusion Medicine, Orebro University Hospital, Orebro, Sweden. berseus@telia.com},
	address = {United States},
	abstract = {BACKGROUND: The increasing use of fresh blood group O whole blood in acute trauma medicine makes it important to reevaluate the issue of hemolytic reactions related to the transfusion of ABO-incompatible plasma., STUDY DESIGN AND METHODS: This review summarizes and evaluates published articles and case reports concerning hemolytic reactions in connection with the transfusion of group O whole blood or blood products to nongroup O recipients., RESULTS: In 1945-1986, 15 nonmilitary publications reported hemolytic transfusion reactions with group O blood/blood products. All patients recovered except for two fatalities. Late in World War II and during the Korean and Vietnam wars and onward in Iraq and Afghanistan only "low anti-A, anti-B titer" group O whole blood has been used as universal blood. In spite of a large number of units transfused, there are no reports of hemolytic reactions. Twenty-five publications report hemolytic reactions after transfusion of group O platelets to nongroup O recipients. In all patients but one, the titer of the implicated A- or B-antibody was >100 (saline) or >400 (antiglobulin) and all cases with an infused volume of incompatible plasma <200mL were related to anti-A or anti-B antiglobulin titers >1000., CONCLUSION: In emergency lifesaving resuscitation, the risk of hemolytic transfusion reactions from transfusion of group O blood to nongroup O recipients constitutes risk that is outweighed by the benefits. A low titer of anti-A/B will minimize the risk for a hemolytic reaction, particularly if the screening is repeated after an immunization episode, e.g., blood transfusion, vaccination, or pregnancy.Copyright {\textcopyright} 2013 American Association of Blood Banks.},
	keywords = {*Blood Component Transfusion/ae [Adverse Effects], *Blood Component Transfusion/mo [Mortality], *Blood Group Incompatibility/mo [Mortality], *Wounds and Injuries/mo [Mortality], ABO Blood-Group System/im [Immunology], Blood Group Incompatibility/im [Immunology], Hemolysis/im [Immunology], Humans, Plasma/im [Immunology], Risk Factors},
	isbn = {1537-2995},
	author = {Berseus, Olle and Boman, Kjell and Nessen, Shawn C and Westerberg, Lars A}
}
