@article {4342,
	title = {Transfusion-associated circulatory overload after plasma transfusion.},
	journal = {//Transfusion},
	volume = {52},
	year = {2012},
	month = {2012},
	pages = {160 - 165},
	publisher = {(1)From the Department of Pathology, Allegheny General Hospital; the Department of Pathology, University of Pittsburgh; and The Institute for Transfusion Medicine, Pittsburgh, Pennsylvania.},
	address = {Copyright (C) 2012 Blackwell Publishing Ltd.},
	abstract = {BACKGROUND: In 2010, transfusion-associated circulatory overload (TACO) was the second most common cause of transfusion-related mortality reported to the Food and Drug Administration. We sought to determine the rate of TACO caused by plasma transfusion., STUDY DESIGN AND METHODS: This study was conducted in two parts: 1) A retrospective analysis to determine the prevalence of TACO reactions caused by plasma at a tertiary care hospital from 2003 to 2010 was performed by analyzing the blood bank{\textquoteright}s electronic transfusion reaction records and 2) active surveillance of plasma recipients to determine if unreported TACO reactions had occurred over a 1-month period at the same hospital., RESULTS: Eighty-seven reactions to plasma had been reported to the blood bank from 2003 through 2010. Of these reactions 23\% (20/87) were TACO. The historical prevalence rate of TACO was 1 in 1566 (95\% confidence interval [CI], 1:2564-1:1014). During the prospective 1-month surveillance period, 84 patients received a total of 272 units of plasma, and four TACO reactions in separate patients (4.8\%) were identified, none of which were reported to the blood bank. The prevalence rate of TACO in the prospective study was 1 in 68 (95\% CI, 1:250-1:27). In total, most patients (14/24) were in the intensive care unit when they experienced TACO and on average they had received 4.0 +/- 2.3 units of plasma at an average rate of 647 +/- 315 mL/hr before the TACO reaction., CONCLUSIONS: Passive reporting of TACO grossly underestimates its actual prevalence. Educational efforts are needed to enhance physician recognition of TACO reactions., Copyright (C) 2012 Blackwell Publishing Ltd.},
	isbn = {0041-1132},
	author = {Narick, Christina and Triulzi, Darrell and Yazer, Mark}
}
