@article {4220,
	title = {New autoimmune diseases after cord blood transplantation: a retrospective study of EUROCORD and the Autoimmune Disease Working Party of the European Group for Blood and Marrow Transplantation.},
	journal = {Blood//Blood},
	volume = {121},
	year = {2013},
	month = {2013},
	pages = {1059 - 64},
	publisher = {Daikeler,Thomas. Eurocord, Hopital Saint Louis Assistance Publique des Hopitaux de Paris (AP-HP), University Paris VII, Paris, France. tdaikeler@uhbs.ch},
	address = {United States},
	abstract = {To describe the incidence, risk factors, and treatment of autoimmune diseases (ADs) occurring after cord blood transplantation (CBT), we analyzed both CBT recipients reported to EUROCORD who had developed at least 1 new AD and those who had not. Fifty-two of 726 reported patients developed at least 1 AD within 212 days (range, 27-4267) after CBT. Cumulative incidence of ADs after CBT was 5.0\% +/- 1\% at 1 year and 6.6\% +/- 1\% at 5 years. Patients developing ADs were younger and had more nonmalignant diseases (P < .001). ADs target hematopoietic (autoimmune hemolytic anemia, n = 20; Evans syndrome, n = 9; autoimmune thrombocytopenia, n = 11; and immune neutropenia, n = 1) and other tissues (thyroiditis, n = 3; psoriasis, n = 2; Graves disease, n 1; membranous glomerulonephritis, n = 2; rheumatoid arthritis, n = 1; ulcerative colitis, n = 1; and systemic lupus erythematosus, n = 1). Four patients developed 2 ADs (3 cases of immune thrombocytopenia followed by autoimmune hemolytic anemia and 1 Evans syndrome with rheumatoid arthritis). By multivariate analysis, the main risk factor for developing an AD was nonmalignant disease as an indication for CBT (P = .0001). Hematologic ADs were most often treated with steroids, rituximab, and cyclosporine. With a median follow-up of 26 months (range, 2-91), 6 of 52 patients died as a consequence of ADs. We conclude that CBT may be followed by potentially life-threatening, mainly hematologic ADs.},
	keywords = {*Autoimmune Diseases/et [Etiology], *Cord Blood Stem Cell Transplantation/ae [Adverse Effects], *Outcome Assessment (Health Care)/sn [Statistics \& Numerical Data], *Risk Assessment/sn [Statistics \& Numerical Data], Adolescent, Adult, Aged, Antibodies, Monoclonal, Murine-Derived/tu [Therapeutic Use], Autoimmune Diseases/dt [Drug Therapy], Child, Child, Preschool, Cyclosporine/tu [Therapeutic Use], Female, Follow-Up Studies, Humans, Immunologic Factors/tu [Therapeutic Use], Immunosuppressive Agents/tu [Therapeutic Use], Infant, Male, Middle Aged, Multivariate Analysis, Outcome Assessment (Health Care)/mt [Methods], Retrospective Studies, Risk Assessment/mt [Methods], Risk Factors, Steroids/tu [Therapeutic Use], Survival Analysis, Young Adult},
	isbn = {1528-0020},
	author = {Daikeler, Thomas and Labopin, Myriam and Ruggeri, Annalisa and Crotta, Alessandro and Abinun, Mario and Hussein, Ayad Ahmed and Carlson, Kristina and Cornillon, Jerome and Diez-Martin, Jose L and Gandemer, Virginie and Faraci, Maura and Lindemans, Caroline and O{\textquoteright}Meara, Anne and Mialou, Valerie and Renard, Marleen and Sedlacek, Petr and Sirvent, Anne and Socie, Gerard and Sora, Federica and Varotto, Stefania and Sanz, Jaime and Voswinkel, Jan and Vora, Ajay and Yesilipek, M Akif and Herr, Andree-Laure and Gluckman, Eliane and Farge, Dominique and Rocha, Vanderson}
}
