@article {4076,
	title = {Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation.},
	journal = {//Bone Marrow Transplant},
	volume = {40},
	year = {2007},
	month = {2007},
	pages = {563 - 566},
	publisher = {(1)Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, Houston, TX, USA; (2)Department of Virology, Barts and The London NHS Trust, London, UK and (3)Division of Infection and Immunity, Centre for Virology, Royal Free and},
	address = {Copyright (C) 2007 Nature Publishing Group},
	abstract = {Human herpesvirus 6 (HHV-6) viremia, as detected by polymerase chain amplification, occurs in approximately half of allogeneic hematopoietic stem cell transplant recipients. The significance of such viremia is incompletely understood, but HHV-6 encephalitis and bone marrow suppression are increasingly being recognized in patients with high viral DNA. We report two patients in whom donor-to-recipient transmission occurred through hematopoietic transplant by means of chromosomally integrated (CI) HHV-6. Iatrogenic transmission manifested at engraftment as asymptomatic elevation of HHV-6 viral DNA of 3600 and 15 400 DNA copies/ml in plasma and 6.1 x 106 and 9.7 x 105 DNA copies/ml in the whole blood. Both donors had elevated plasma HHV-6 PCR at 5.6 x 104 and 1.3 x 105 DNA copies/ml and strikingly elevated whole blood HHV-6 levels at 4.1 x 106 and 4.7 x 106 DNA copies/ml, respectively. CI of the virus was traced to the mother of one patient and his donor. CI of HHV-6 may confound the interpretation of HHV-6 viremia after stem cell transplantation; consideration of the possibility of CI HHV-6 will avoid unnecessary antiviral therapy., Copyright (C) 2007 Nature Publishing Group},
	keywords = {allogeneic transplant, chromosomal integration, human herpesvirus-6},
	isbn = {0268-3369},
	author = {Kamble, R and Clark, D and Leong, H and Heslop, H and Brenner, M and Carrum, G}
}
