@article {1854,
	title = {De novo hepatitis B after liver transplantation from hepatitis B core antibody-positive donors in an area with high prevalence of anti-HBc positivity in the donor population.},
	volume = {7},
	year = {2001},
	note = {Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Print; NLM Journal Code: dk0, 100909185},
	month = {Jan},
	pages = {1},
	address = {UNITED STATES},
	abstract = {Transmission of hepatitis B virus (HBV) infection from donors who are negative for hepatitis B surface antigen (HBsAg-) but positive for antibody to hepatitis B core antigen (anti-HBc+) has been reported. However, previous studies were generally performed in geographic regions with a low prevalence of anti-HBc positivity in the liver donor population. The aims of this study are (1) to assess the risk for de novo hepatitis B in recipients of livers from anti-HBc+ donors in an area of high prevalence of anti-HBc positivity in the donor population, and (2) to analyze the risk factors for acquisition of HBV infection from anti-HBc+ donors. The transplantation experience of a single center between 1995 and 1998 was reviewed. Thirty-three of 268 liver donors (12\%) were HBsAg- and anti-HBc+ during the study period. The proportion of anti-HBc+ donors increased with age; it was lowest (3.6\%) in donors aged 1 to 20 years and highest (27.1\%) in donors aged older than 60 years. Of the 211 HBsAg- recipients with 3 months or more of HBV serological follow-up, 30 received a liver from an anti-HBc+ donor and 181 received a liver from an anti-HBc- donor. Hepatitis B developed in 15 of 30 recipients (50\%) of livers from anti-HBc+ donors but in only 3 of 181 recipients (1.7\%) of livers from anti-HBc- donors (P < .0001). None of the 4 recipients who were antibody to HBsAg (anti-HBs)+ at the time of transplantation developed HBV infection after receiving a liver from an anti-HBc+ donor compared with 15 of 26 recipients (58\%) who were anti-HBs- (P =.10). None of the 5 anti-HBc+ recipients developed hepatitis B compared with 15 of 25 anti-HBc- recipients (60\%; P = 0.04). Child-Pugh score was significantly higher in recipients of livers from anti-HBc+ donors who developed HBV infection than in those who did not (9 +/- 2 v 7 +/- 1; P =.03). In our area, testing liver donors for anti-HBc is mandatory, particularly in older donors. With such information available, anti-HBc+ donors can be safely directed to appropriate recipients, mainly those with anti-HBs and/or anti-HBc at the time of transplantation. In the current era of donor shortage, this policy would allow adequate use of such donors.},
	keywords = {Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, Hepatitis B / mo [Mortality], Hepatitis B / tm [Transmission], Hepatitis B Antibodies / bl [Blood], Hepatitis B Core Antigens / im [Immunology], Hepatitis B Surface Antigens / bl [Blood], Humans, IM, Infant, Liver Transplantation / ae [Adverse Effects], Male, Middle Aged, Seroepidemiologic Studies, Spain / ep [Epidemiology], Survival Rate, Tissue Donors},
	issn = {1527-6465; 1527-6465},
	author = {Prieto,M. and Gomez,M. D. and Berenguer,M. and Cordoba,J. and Rayon,J. M. and Pastor,M. and Garcia-Herola,A. and Nicolas,D. and Carrasco,D. and Orbis,J. F. and Mir,J. and Berenguer,J.}
}
