@article {1857,
	title = {Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.},
	volume = {113},
	year = {1997},
	note = {Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Print; NLM Journal Code: fh3, 0374630; Grant Number: N01-DK-0-2251 (United States NIDDK NIH HHS), N01-DK-0-2252 (United States NIDDK NIH HHS), N01-DK-0-2253 (United States NIDDK NIH HHS) etc.},
	month = {Nov},
	pages = {8},
	address = {UNITED STATES},
	abstract = {<p>BACKGROUND \&amp; AIMS: Organ donors are a potential source of transmissible disease after transplantation. The aim of this study was to evaluate the risk of acquiring hepatitis B among transplantation recipients of livers from donors without serum hepatitis B surface antigen (HBsAg) but with antibody to hepatitis B core antigen (anti-HBc). METHODS: The transplantation experience of four centers between 1989 and 1994 was reviewed. Recipients of livers from 674 donors were considered informative for hepatitis B virus transmission. RESULTS: Hepatitis B developed in 18 of 23 recipients of livers from anti-HBc-positive donors (78\%) compared with only 3 of 651 recipients of anti-HBc-negative donor livers (0.5\%) (P \&lt; 0.0001). HBsAg persisted in all recipients with donor-related hepatitis B. Liver histology showed chronic hepatitis of moderate severity in 2 of 13 recipients at 1 year and 5 of 8 recipients between 1.6 and 4.5 years from transplantation. Liver transplantation from an anti-HBc-positive donor was associated with decreased 4-year survival (adjusted mortality hazard ratio of 2.4; 95\% confidence interval, 1.4-4.0). CONCLUSIONS: De novo posttransplantation hepatitis B infection occurs at a high rate in recipients of donors with anti-HBc. Transmission of hepatitis B through transplantation suggests that the virus may persist in the liver despite serological resolution of infection.</p>
},
	keywords = {AIM, IM, Hepatitis B / tm [Transmission], Hepatitis B Antibodies / bl [Blood], Hepatitis B Core Antigens / im [Immunology], Hepatitis B Surface Antigens / im [Immunology], Humans, Liver Transplantation / ae [Adverse Effects], Tissue Donors},
	issn = {0016-5085; 0016-5085},
	author = {Dickson,R. C. and Everhart,J. E. and Lake,J. R. and Wei,Y. and Seaberg,E. C. and Wiesner,R. H. and Zetterman,R. K. and Pruett,T. L. and Ishitani,M. B. and Hoofnagle,J. H.}
}
