@article {1692,
	title = {Plasmodium falciparum causing hemophagocytic syndrome after allogeneic blood stem cell transplantation},
	journal = {The hematology journal : the official journal of the European Haematology Association / EHA},
	volume = {5},
	year = {2004},
	note = {JID: 100965523; 0 (Antimalarials); 130-95-0 (Quinine); ppublish},
	pages = {449 - 450},
	address = {England},
	abstract = {We describe a case of Plasmodium falciparum infection in a 25-year-old male patient with a myelodysplastic syndrome, who underwent allogeneic peripheral blood stem cell transplantation (PBSCT) in September 2003. Conditioning regimen consisted of total body irradiation (10 Gy) and cyclophosphamide 60 mg/kg for 2 days. A dose of 4 x 10(6) CD34+ cells/kg was transfused. Engraftment was well documented on day 17 post-transplantation. Spiking fevers occurred on days 19 and 21, associated with a pancytopenia, hepatosplenomegaly and neurological signs. P. falciparum parasites were found on the peripheral blood smear (parasitemia = 23\%). Marrow aspiration showed P. falciparum parasites and proliferation of mature histiocytes with hemophagocytosis. Quinine 10 mg/kg i.v. three times a day for 10 consecutive days was given. The fever subsided within 3 days, and pancytopenia vanished in 14 days. Parasitemia cleared in 6 days. The patient left the unit on day 46 with no further complications. The screening of donors showed that infection was acquired from two blood units (from a single donor) given 5 days before transplantation. We report the first case of profound hemophagocytosis in immunosuppressed patient with malaria of high parasitemia after a bone marrow transplant.},
	keywords = {Adult, Animals, Antimalarials / therapeutic use, Blood Donors, Blood Transfusion / adverse effects, Disease Susceptibility, Erythrocytes / parasitology, Histiocytosis, Non-Langerhans-Cell / etiology, Humans, Leukemia, Myelomonocytic, Chronic / complications / therapy, Malaria, Falciparum / complications / drug therapy / transmission, Male, Parasitemia / complications / drug therapy / transmission, Peripheral Blood Stem Cell Transplantation, Plasmodium falciparum / isolation \& purification, Quinine / therapeutic use, Remission Induction, Transplantation Conditioning, Transplantation, Homologous},
	issn = {1466-4860; 1466-4860},
	doi = {10.1038/sj.thj.6200531},
	author = {Abdelkefi,A. and Ben Othman,T. and Torjman,L. and Ladeb,S. and Lakhal,A. and Belhadj,S. and Ayari,S. and Cherif,N. and Ben Achour,O. and Chaker,E. and Ben Abdeladhim,A.}
}
