@article {1685,
	title = {The Italian multiorgan donor cancer screening protocol: 2002-2005 experience},
	journal = {Transplantation},
	volume = {85},
	year = {2008},
	note = {Zucchini, Nicola Fiorentino, Michelangelo D{\textquoteright}Errico Grigioni, Antonia Rizzato, Lucia Venettoni, Sante Nanni Costa, Alessandro Grigioni, Walter F Italian Transplant Research Network United States Transplantation Transplantation. 2008 Apr 27;85(8 Suppl):S57-60.},
	month = {46478},
	pages = {S57 - 60},
	edition = {39613},
	abstract = {BACKGROUND: We describe the results of the application of the Italian donor cancer screening protocol to all the 7608 candidate multiorgan donors presented in Italy in 2002-2005. METHODS: All suspect findings raised in the two presurgical and surgical phases of the protocol were investigated by extemporary pathologic evaluation. Donors were classified as standard risk (no transmissible risk); nonstandard risk (low-risk of transmission, eligibility restricted to certified clinical emergencies pending informed consent); and unacceptable risk (unconditional exclusion because of high-risk pathologies). RESULTS: The protocol was successfully implemented for all 7608 candidates. In addition to 8 (0.1\%) independent exclusions, clinical suspicion of cancer was raised for 337 (4.6\%) donors. According to pathological examination 198 donors (2.6\%) were judged at unacceptable risk of tumor transmission; 80 (1\%) were included in the "standard risk". Used standard risk and nonstandard risk donors provided a total of 241 organs in 231 recipients. Although no suspect was raised after implementation of the protocol, a malignant tumor was discovered after organ transplantation in 14 (0.2\%) donors. All the recipients transplanted with organs from ascertained nonstandard risk donors or from neoplastic donors who donated by accident have been carefully followed. At the time of most recent follow-up no donor/recipient tumor transmission has been reported. CONCLUSIONS: Implementation of the multiorgan cancer screening protocol is feasible at a national level in Italy. In view of the increasing demand for organs our protocol provides a useful tool for rationalization of the use of organs from neoplastic marginal donors.},
	keywords = {*Patient Selection, *Tissue Donors, Female, Humans, Italy, Male, Mass Screening / *methods, Neoplasms / *epidemiology, Risk Assessment},
	issn = {0041-1337 (Print) 0041-1337 (Linking)},
	doi = {10.1097/TP.0b013e31816c2d42 00007890-200804271-00004 [pii]},
	author = {Zucchini,N. and Fiorentino,M. and D{\textquoteright}Errico Grigioni,A. and Rizzato,L. and Venettoni,S. and Nanni Costa,A. and Grigioni,W. F.}
}
