@article {1615,
	title = {Cytomegalovirus keratitis after penetrating keratoplasty},
	journal = {Cornea},
	volume = {14},
	year = {1995},
	note = {Wehrly, S R Manning, F J Proia, A D Burchette, J L Foulks, G N Case Reports United states Cornea Cornea. 1995 Nov;14(6):628-33.},
	month = {Nov},
	pages = {628 - 33},
	edition = {35004},
	abstract = {We report the development of cytomegalovirus (CMV) keratitis in the penetrating keratoplasty of a 59-year-old human immunodeficiency virus-negative woman after uncomplicated corneal transplantation. Immunosuppression with topical cyclosporine A 2\% in corn oil and topical prednisolone acetate 1\% suspension was used postoperatively. The 15-month postoperative course was complicated by multiple episodes of endothelial rejection, medically controlled elevated intraocular pressure, polymicrobial bacterial (coagulase-negative staphlococcus and alpha-hemolytic streptococcus) keratitis, and endothelial plaque formation with associated hypopyon and epithelial defect. The graft failed and penetrating keratoplasty was repeated. Cytomegalovirus infection of superficial keratocytes in a region of scarring was identified in histological sections stained with hematoxylin and eosin and confirmed using mouse monoclonal anti-cytomegalovirus antibodies. Excision of the diseased corneal button with no additional treatment appears to have been curative. Low-grade keratitis was the only manifestation of the CMV infection, and it has not recurred 6 months postoperatively.},
	keywords = {Anti-Inflammatory Agents / administration \& dosage, Antibodies, Monoclonal, Antigens, Viral / analysis, Cornea / pathology / surgery / virology, Corneal Stroma / pathology / virology, Cyclosporine / administration \& dosage, Cytomegalovirus / immunology, Cytomegalovirus Infections / *etiology / pathology, Eye Infections, Viral / *etiology / pathology, Female, Graft Rejection / drug therapy / etiology, Humans, Immunoenzyme Techniques, Immunosuppressive Agents / administration \& dosage, Keratitis / pathology / *virology, Keratoplasty, Penetrating / *adverse effects, Middle Aged, Ophthalmic Solutions, Prednisolone / administration \& dosage, Reoperation},
	issn = {0277-3740 (Print) 0277-3740 (Linking)},
	url = {internal-pdf://Wehrly - CMV-3364790785/Wehrly - CMV.pdf},
	author = {Wehrly,S. R. and Manning,F. J. and Proia,A. D. and Burchette,J. L. and Foulks,G. N.}
}
