@article {1596,
	title = {Bacterial keratitis after penetrating keratoplasty: incidence, microbiological profile, graft survival, and visual outcome},
	journal = {Ophthalmology},
	volume = {114},
	year = {2007},
	note = {Wagoner, Michael D Al-Swailem, Samar A Sutphin, John E Zimmerman, M Bridgett United States Ophthalmology Ophthalmology. 2007 Jun;114(6):1073-9. Epub 2007 Feb 1.},
	month = {Jun},
	pages = {1073 - 9},
	edition = {39119},
	abstract = {PURPOSE: To determine the incidence, microbiological profile, graft survival, and factors influencing graft survival after the development of bacterial keratitis after penetrating keratoplasty (PK). DESIGN: Retrospective case series. PARTICIPANTS: One hundred two patients (102 eyes) treated at a single center during a 5-year period. METHODS: Retrospective review of the medical records of every patient treated for culture-positive keratitis between January 1, 1998 and December 31, 2002 who previously had undergone penetrating keratoplasty at the King Khaled Eye Specialist Hospital. MAIN OUTCOME MEASURES: Graft survival and visual outcome. RESULTS: There were 2103 PKs performed and 102 (4.9\%) cases of culture-positive keratitis during the study period. There were 168 bacterial isolates, of which 140 (83.3\%) were gram positive, 28 (16.7\%) were gram negative, and 1 (0.6\%) was acid fast. Only 38 (37.3\%) grafts remained clear after a mean follow-up of 985 days (range, 82-2284). The best graft survival was in eyes with PK for keratoconus (83.7\%), whereas the poorest grat survival was for previously failed grafts (5.6\%). By Kaplan-Meier analysis, there was an immediate steep decline in graft survival to 54.9\%, followed by a slow decline to 47.2\% by 1 year and 35.8\% after 4 years. Factors associated with an increased risk of graft failure were the surgical indication for PK (P or =20/40 in only 8 (8.2\%) eyes and better than 20/200 in only 21 (21.6\%) eyes. CONCLUSION: The development of bacterial keratitis after PK is a serious complication that is associated with a high incidence of graft failure and poor visual outcome.},
	keywords = {*Graft Survival, *Keratoplasty, Penetrating, *Postoperative Complications, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents / therapeutic use, Bacteria / isolation \& purification, Child, Child, Preschool, Eye Infections, Bacterial / drug therapy / epidemiology / *microbiology, Female, Humans, Incidence, Infant, Keratitis / drug therapy / epidemiology / *microbiology, Male, Middle Aged, Retrospective Studies, Visual Acuity / *physiology},
	issn = {1549-4713 (Electronic) 0161-6420 (Linking)},
	doi = {S0161-6420(06)01372-8 [pii] 10.1016/j.ophtha.2006.10.015},
	url = {internal-pdf://Wagoner - Bacterial keratitis-0663932416/Wagoner - Bacterial keratitis.pdf},
	author = {Wagoner,M. D. and Al-Swailem,S. A. and Sutphin,J. E. and Zimmerman,M. B.}
}
