@article {1591,
	title = {Trypanosoma cruzi trans-sialidase inhibits human lymphocyte proliferation by nonapoptotic mechanisms: implications in pathogenesis and transplant immunology},
	journal = {Transplant Proc},
	volume = {37},
	year = {2005},
	note = {Vercelli, C A Hidalgo, A M Hyon, S H Argibay, P F Research Support, Non-U.S. Gov{\textquoteright}t United States Transplantation proceedings Transplant Proc. 2005 Dec;37(10):4594-7.},
	month = {Dec},
	pages = {4594 - 7},
	edition = {38720},
	abstract = {Chiefly an intracellular parasite, Trypanosoma cruzi has a transient blood-borne stage (trypomastigote), the acute phase of Chagas{\textquoteright} disease, during which surface trans-sialidase is expressed and shed by the parasite. It{\textquoteright}s immunosuppressive through the induction of apoptosis. Herein, we investigated the role of trans-sialidase as an immune modulator of allo- and xenoreactions. Trans-sialidase strongly inhibited human lymphocyte proliferation; a role for the interleukin-2 receptor CD25 was suggested by flow cytometry. These results may have implications both for the pathogenesis of Chagas{\textquoteright} disease and for transplantation immunology.},
	keywords = {*Transplantation Immunology, Animals, Antigens, CD / analysis, Apoptosis / drug effects, Cell Division / drug effects, Cell Transplantation / *methods, Glycoproteins / *pharmacology, Humans, Lymphocyte Culture Test, Mixed, Lymphocytes / *cytology / drug effects, Mice, Neuraminidase / *pharmacology, Trypanosoma cruzi / *enzymology},
	issn = {0041-1345 (Print) 0041-1345 (Linking)},
	doi = {S0041-1345(05)01175-9 [pii] 10.1016/j.transproceed.2005.10.013},
	author = {Vercelli,C. A. and Hidalgo,A. M. and Hyon,S. H. and Argibay,P. F.}
}
