@article {1580,
	title = {The influence of contamination of culture medium with hepatitis B virus on the outcome of in vitro fertilization pregnancies},
	journal = {Am J Obstet Gynecol},
	volume = {165},
	year = {1991},
	note = {van Os, H C Drogendijk, A C Fetter, W P Heijtink, R A Zeilmaker, G H Case Reports United states American journal of obstetrics and gynecology},
	month = {Jul},
	pages = {152 - 9},
	edition = {33420},
	abstract = {Heat-inactivated human serum is added to the culture medium used for in vitro fertilization and other forms of assisted conception. Because one batch of pooled serum contained hepatitis B virus, an epidemic occurred among women participating in the treatment program. Seventy-nine women had serologic proof of hepatitis B infection. This incident gave the opportunity to study the effect of hepatitis B virus on pregnancy outcome and the newborn. The situation is unique because the preimplantation embryo was exposed to hepatitis B virus or the pregnancy was complicated by a (sub)clinical infection. Twenty-four women were or became pregnant while having an acute hepatitis B infection. Five pregnancies ended in abortion. The remaining 19 pregnancies ended in the birth of 24 children. No evidence for any harmful effect of exposure to hepatitis B virus in the embryonic or fetal period on the newborn could be found.},
	keywords = {*Culture Media, *Fertilization in Vitro, *Pregnancy Outcome, Adult, Blood / *microbiology, Cerebral Ventricles / abnormalities, Delivery, Obstetric, Female, Fetal Blood / immunology, Hepatitis B / microbiology / therapy, Hepatitis B Surface Antigens / analysis, Hepatitis B virus / *isolation \& purification, Humans, Immunotherapy, Pregnancy, Pregnancy, Multiple, Prenatal Diagnosis},
	issn = {0002-9378 (Print) 0002-9378 (Linking)},
	doi = {0002-9378(91)90244-L [pii]},
	author = {van Os,H. C. and Drogendijk,A. C. and Fetter,W. P. and Heijtink,R. A. and Zeilmaker,G. H.}
}
