@article {1556,
	title = {Analysis of factors that influence survival with post-transplant lymphoproliferative disorder in renal transplant recipients: the Israel Penn International Transplant Tumor Registry experience},
	journal = {Am J Transplant},
	volume = {5},
	year = {2005},
	note = {1600-6135 (Print) Journal Article},
	month = {Apr},
	pages = {775 - 80},
	abstract = {Significant mortality is associated with post-transplant lymphoproliferative disorder (PTLD) in kidney transplant recipients (KTX). Univariate/multivariate risk factor survival analysis of US PTLD KTX reported to Israel Penn International Transplant Tumor Registry from November 1968 to January 2000 was performed. PTLD presented 18 (median) (range 1-310) months in 402 KTX. Death rates were greater for those diagnosed within 6 months (64\%) versus beyond 6 months (54\%, p = 0.04). No differences in death risk for gender, race, immunosuppression, EBV, B or T cell positivity were identified. Death risk increased for multiple versus single sites (73\% vs. 53\%, hazards ratio (HR) 1.4). A 1-year increase in age increased HR for death by 2\%. Surgery was associated with increased survival (55\% vs. 0\% without surgery) (p < 0.0001). Patients with allograft involvement, treated with transplant nephrectomy alone (n = 20), had 80\% survival versus 53\% without allograft removal (n = 15) (p < 0.001). Overall survival was 69\% for allograft involvement alone versus 36\% for other organ involvement plus allograft (n = 19 alive) (p < 0.0001). Death risk was greater for multiple site PTLD and increasing age, and risks were additive. Univariate analysis identified increased death risk for those not receiving surgery, particularly allograft involvement alone.},
	keywords = {*Kidney Transplantation, *Registries, *Survival, Graft Rejection / prevention \& control, Immunosuppression, Lymphoproliferative Disorders / *mortality / physiopathology / therapy, Survival Analysis},
	author = {Trofe,J. and Buell,J. F. and Beebe,T. M. and Hanaway,M. J. and First,M. R. and Alloway,R. R. and Gross,T. G. and Succop,P. and Woodle,E. S.}
}
