@article {1551,
	title = {Rapid development of subacute myelopathy in three organ transplant recipients after transmission of human T-cell lymphotropic virus type I from a single donor},
	journal = {Transplantation},
	volume = {75},
	year = {2003},
	note = {Toro, Carlos Rodes, Berta Poveda, Eva Soriano, Vincent Case Reports Comment Research Support, Non-U.S. Gov{\textquoteright}t United States Transplantation Transplantation. 2003 Jan 15;75(1):102-4.},
	month = {Jan 15},
	pages = {102 - 4},
	edition = {37646},
	abstract = {BACKGROUND: Human T-cell lymphotropic virus type I (HTLV-I) causes a subacute myelopathy in less than 5\% of chronic carriers. However, the risk of neurologic disease appears to increase in persons infected through blood transfusion. METHODS: We report three recipients of solid organ transplants who developed a subacute myelopathy within 2 years after becoming infected with HTLV-I from a single asymptomatic HTLV-I donor. Genetic studies were performed in and sequences in proviral DNA, and HTLV-I proviral load was measured by real-time quantitative polymerase chain reaction. RESULTS: HTLV-I sequences were obtained in two of these individuals, and they were almost identical and clustered within the Cosmopolitan A HTLV-I subtype, which indicates a common source. All typical changes in Tax amino acid sequence of the HTLV-I Cosmopolitan A were identified, plus two additional changes were noted. Although A has been associated with a greater risk of neurologic disease, both patients were positive for human leukocyte antigen-A*02, which is considered a protective factor. CONCLUSION: Rapid development of subacute myelopathy may occur in recipients of organ transplants from asymptomatic HTLV-I donors. A particular virulence of the virus strain, the large size of the virus inoculum, and the immunosuppressed condition after transplantation may have contributed to produce this unusual rapid development of HTLV-I associated myelopathy.},
	keywords = {*Tissue Donors, Adult, Base Sequence, Female, HTLV-I Infections / *transmission / virology, Human T-lymphotropic virus 1 / classification / isolation \& purification, Humans, Kidney Transplantation / *adverse effects, Liver Transplantation / *adverse effects, Male, Middle Aged, Molecular Sequence Data, Paraparesis, Tropical Spastic / *etiology, Viral Load},
	issn = {0041-1337 (Print) 0041-1337 (Linking)},
	doi = {10.1097/01.TP.0000040428.36030.FC},
	author = {Toro,C. and Rodes,B. and Poveda,E. and Soriano,V.}
}
