@article {1474,
	title = {Epstein-Barr virus-associated post-transplant lympho-proliferative disease of donor origin in liver transplant recipients},
	journal = {J Hepatol},
	volume = {26},
	year = {1997},
	note = {Strazzabosco, M Corneo, B Iemmolo, R M Menin, C Gerunda, G Bonaldi, L Merenda, R Neri, D Poletti, A Montagna, M Del Mistro, A Faccioli, A M D{\textquoteright}Andrea, E Case Reports Research Support, Non-U.S. Gov{\textquoteright}t Denmark Journal of hepatology J Hepatol. 1997 Apr;26(4):926-34.},
	month = {Apr},
	pages = {926 - 34},
	edition = {35521},
	abstract = {BACKGROUND/AIMS: Post-transplant lymphoproliferative disease, a potential complication of solid organ transplantation, occurs in about 3\% of orthotopic liver transplant recipients. We report the genetic and virological characterization of two cases of post-transplant lymphoproliferative disease that occurred early (4 and 6 months) after orthotopic liver transplant as large-cell non-Hodgkin{\textquoteright}s lymphomas located at the hepatic hilum. METHODS: Lymphomatous tissues were analyzed for clonality and presence of Epstein-Barr virus (EBV) sequences by Southern blot, polymerase chain reaction, and in situ hybridization techniques. RESULTS: The tumors in both cases were sustained by a clonal proliferation of B lymphocytes containing type A EBV DNA. Moreover, in situ hybridization with a digoxigenin-labeled EBV-specific probe evidenced a strong nuclear signal in most of the neoplastic cells. DNA microsatellite analysis at three different loci detected alleles of donor origin in both tumor samples, suggesting that the neoplastic B cells were of donor origin. CONCLUSIONS: EBV-infected donor B lymphocytes might be responsible for intragraft post-transplant lymphoproliferative disease in orthotopic liver transplant recipients. As 20 to 30\% of post-transplant lymphomas involve the graft itself, donor-derived post-transplant lymphoproliferative disease might be more frequent than presently appreciated. Prospective studies are needed to assess its real incidence and identify possible risk factors.},
	keywords = {*Herpesvirus 4, Human, *Tissue Donors, B-Lymphocytes / pathology, Cell Line, Herpesviridae Infections / *etiology / pathology / radiography, Humans, Liver Transplantation / *adverse effects, Lymphoproliferative Disorders / *etiology / genetics / *virology, Male, Microsatellite Repeats, Middle Aged, Tomography, X-Ray Computed, Tumor Virus Infections / *etiology / pathology / radiography},
	issn = {0168-8278 (Print) 0168-8278 (Linking)},
	doi = {S0168827897802620 [pii]},
	author = {Strazzabosco,M. and Corneo,B. and Iemmolo,R. M. and Menin,C. and Gerunda,G. and Bonaldi,L. and Merenda,R. and Neri,D. and Poletti,A. and Montagna,M. and Del Mistro,A. and Faccioli,A. M. and D{\textquoteright}Andrea,E.}
}
