@article {1436,
	title = {Transmission of rabies virus from an organ donor to four transplant recipients},
	journal = {N Engl J Med},
	volume = {352},
	year = {2005},
	note = {Srinivasan, Arjun Burton, Elizabeth C Kuehnert, Matthew J Rupprecht, Charles Sutker, William L Ksiazek, Thomas G Paddock, Christopher D Guarner, Jeannette Shieh, Wun-Ju Goldsmith, Cynthia Hanlon, Cathleen A Zoretic, James Fischbach, Bernard Niezgoda, Michael El-Feky, Waleed H Orciari, Lillian Sanchez, Edmund Q Likos, Anna Klintmalm, Goran B Cardo, Denise LeDuc, James Chamberland, Mary E Jernigan, Daniel B Zaki, Sherif R Rabies in Transplant Recipients Investigation Team United States The New England journal of medicine N Engl J Med. 2005 Mar 17;352(11):1103-11.},
	month = {42795},
	pages = {1103 - 11},
	edition = {38435},
	abstract = {BACKGROUND: In 2004, four recipients of kidneys, a liver, and an arterial segment from a common organ donor died of encephalitis of an unknown cause. METHODS: We reviewed the medical records of the organ donor and the recipients. Blood, cerebrospinal fluid, and tissues from the recipients were tested with a variety of assays and pathological stains for numerous causes of encephalitis. Samples from the recipients were also inoculated into mice. RESULTS: The organ donor had been healthy before having a subarachnoid hemorrhage that led to his death. Encephalitis developed in all four recipients within 30 days after transplantation and was accompanied by rapid neurologic deterioration characterized by agitated delirium, seizures, respiratory failure, and coma. They died an average of 13 days after the onset of neurologic symptoms. Mice inoculated with samples from the affected patients became ill seven to eight days later, and electron microscopy of central nervous system (CNS) tissue demonstrated rhabdovirus particles. Rabies-specific immunohistochemical and direct fluorescence antibody staining demonstrated rabies virus in multiple tissues from all recipients. Cytoplasmic inclusions consistent with Negri bodies were seen in CNS tissue from all recipients. Antibodies against rabies virus were present in three of the four recipients and the donor. The donor had told others of being bitten by a bat. CONCLUSIONS: This report documenting the transmission of rabies virus from an organ donor to multiple recipients underscores the challenges of preventing and detecting transmission of unusual pathogens through transplantation.},
	keywords = {*Disease Transmission, Infectious, Antibodies, Viral / blood, Brain / pathology / ultrastructure / virology, Central Nervous System / virology, Encephalitis, Viral / *virology, Humans, Iliac Artery / *transplantation, Kidney Transplantation / *adverse effects, Liver Transplantation / *adverse effects, Male, Rabies / *transmission / virology, Rabies virus / immunology / *isolation \& purification, Subarachnoid Hemorrhage, Tissue Donors, Tissue Transplantation / adverse effects, Virion / isolation \& purification},
	issn = {1533-4406 (Electronic) 0028-4793 (Linking)},
	doi = {352/11/1103 [pii] 10.1056/NEJMoa043018},
	author = {Srinivasan,A. and Burton,E. C. and Kuehnert,M. J. and Rupprecht,C. and Sutker,W. L. and Ksiazek,T. G. and Paddock,C. D. and Guarner,J. and Shieh,W. J. and Goldsmith,C. and Hanlon,C. A. and Zoretic,J. and Fischbach,B. and Niezgoda,M. and El-Feky,W. H. and Orciari,L. and Sanchez,E. Q. and Likos,A. and Klintmalm,G. B. and Cardo,D. and LeDuc,J. and Chamberland,M. E. and Jernigan,D. B. and Zaki,S. R.}
}
