@article {1288,
	title = {Risk factors for acute graft-versus-host disease after allogeneic blood stem cell transplantation.},
	journal = {Blood},
	volume = {94},
	year = {1999},
	month = {Aug},
	pages = {1465 - 70},
	abstract = {We evaluated demographic characteristics and graft composition as risk factors for acute graft-versus-host disease (GVHD) in 160 adult recipients of HLA-identical allogeneic blood stem cell transplants. The patients received a median nucleated cell dose of 7.9 x 10(8)/kg and median C34(+) cell dose of 5.6 x 10(6)/kg. GVHD prophylaxis consisted of cyclosporine (CSA) and steroids, tacrolimus (FK506) and steroids, or FK506 and methotrexate. Grades 2 to 4 GVHD occurred in 31\% (95\% CI, 23\% to 39\%), and grades 3 to 4 GVHD in 14\% (95\% CI, 8\% to 20\%). In univariate analyses, GVHD prophylaxis with CSA and high CD34(+) cell doses were significant risk factors for grades 2 to 4 GVHD, but diagnosis, age, use of total body irradiation, donor sex, female donor for male recipient, donor parity, donor alloimmunization, viral serology, nucleated cell dose, CD3(+) cell dose, and CD56(+) cell dose did not alter the incidence of GVHD significantly. With a CD34(+) cell dose less than 8 x 10(6) CD34(+) cells/kg, the risk of grades 2 to 4 GVHD was significantly higher for those who received CSA (39\%, 95\% CI, 21\% to 47\%) in comparison with those on FK506 (18\%, 95\% CI, 10\% to 26\%) (P =.03), but GVHD prophylaxis regimen had less impact with a higher CD34(+) cell dose (overall grades 2 to 4 GVHD rate 52\%, 95\% CI, 37\% to 67\%). GVHD prophylaxis and CD34(+) cell dose are independent risk factors for acute GVHD after allogeneic blood stem cell transplantation.},
	keywords = {Adolescent, Adult, Aged, Child, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Histocompatibility Testing, HLA Antigens, Humans, Immunosuppressive Agents, Male, Middle Aged, Risk Factors, Transplantation, Homologous},
	issn = {0006-4971},
	author = {Przepiorka,D. and Smith,T. L. and Folloder,J. and Khouri,I. and Ueno,NT and Mehra,R. and K{\"o}rbling,M. and Huh,Y. O. and Giralt,S. and Gajewski,J. and Donato,M. and Cleary,K. and Claxton,D. and Braunschweig,I. and vanBesien,K. and Andersson,BS and Anderlini,P. and Champlin,R.}
}
