@article {1270,
	title = {Spleen enlargement following recombinant human granulocyte colony-stimulating factor administration for peripheral blood stem cell mobilization},
	journal = {Haematologica},
	volume = {88},
	year = {2003},
	note = {Picardi, Marco},
	month = {Jul},
	pages = {794 - 800},
	edition = {37817},
	abstract = {BACKGROUND AND OBJECTIVES: Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used to mobilize peripheral blood stem cells (PBSC) for autologous or allogeneic transplants. Such treatment may cause spleen enlargement; exceptionally, spontaneous spleen rupture has been reported. We investigated changes in spleen size during stem cell mobilization. DESIGN AND METHODS: We evaluated spleen size, comparing palpation with ultrasound (US)-evaluated longitudinal diameter and volume, in 13 healthy donors and 22 patients with a hematological malignancy who were undergoing PBSC mobilization with rhG-CSF-including regimens. RESULTS: Intraobserver and interobserver variability of US-calculated spleen volume was very low; the correlation between the volume calculated by US and that measured by 3-dimensional computed tomography was excellent. During mobilization, spleen enlargement was detected by palpation in 17\% of subjects, by US-measured longitudinal diameter in 60\%, and by US-calculated volume in 91\%. The median increase in spleen volume was 300 mL (range, 54-820; p<0.001) in healthy donors and 135 mL (range, 0-413; p=0.004) in the group of patients; the enlargement correlated with white blood cell count elevation (p=0.016) but not with circulating CD34+ cells. One month after the last administration of rhG-CSF, the median decrease was 160 mL (range, 35-800) in healthy donors and 58 mL (range, 0-310) in patients. INTERPRETATION AND CONCLUSIONS: When evaluated by sensitive methods, rhG-CSF caused spleen enlargement in almost all individuals treated. US-calculated volume proved to be an excellent method, much better than longitudinal diameter, for detecting non-palpable splenomegaly induced by rhG-CSF.},
	keywords = {Adolescent, Adult, Female, Granulocyte Colony Stimulating Factor, Recombinant / *adverse effects, Hematopoietic Stem Cell Mobilization / *adverse effects, Humans, Leukocyte Count, Male, Middle Aged, Observer Variation, Reference Values, Splenomegaly / *chemically induced / radiography / ultrasonography, Tomography, X-Ray Computed / statistics \& numerical data},
	issn = {1592-8721 (Electronic) 0390-6078 (Linking)},
	author = {Picardi,M. and De Rosa,G. and Selleri,C. and Scarpato,N. and Soscia,E. and Martinelli,V. and Ciancia,R. and Rotoli,B.}
}
