@article {1025, title = {A case of ABO-incompatible renal transplant patient with non-insulin-dependent diabetes mellitus; long-standing observation of serial glomerular change by protocol biopsy}, journal = {Clin Transplant}, volume = {13 Suppl 1}, year = {1999}, note = {Miyagi, M Sakai, K Hasegawa, A Ohara, T Mizuiri, S Aikawa, A Hadano, T Nakano, H Shindo, M Ishikawa, Y Hasegawa, C Hirayama, N Arai, K Case Reports Denmark Clinical transplantation Clin Transplant. 1999;13 Suppl 1:43-7.}, pages = {43 - 7}, edition = {36622}, abstract = {A 41-yr-old patient with non-insulin-dependent diabetes mellitus (NIDDM), before and after ABO-incompatible renal transplant, is reviewed using serial protocol biopsy. Although she recovered from delayed hyperacute rejection (DHAR) immediately post-transplantation, her graft function deteriorated gradually. A mild acute transplant glomerulitis, noted at the 155th day post-transplantation, progressed to pronounced chronic transplant glomerulopathy over 5 yr. In the specimen of the last biopsy, at 5 yr post-transplantation, glomeruli demonstrated an exudative hyaline lesion, which was characteristic of diabetic nephropathy in addition to chronic transplant glomerulopathy. Therefore, we made a diagnosis of this glomerular lesion as chronic transplant glomerulopathy complicated by diabetic glomerulopathy. Considering the result of this case, the protocol biopsy is a useful procedure to diagnose an accurate cause of graft dysfunction in individual cases. It is concluded that the protocol biopsy is apparently useful for the detection of various pathological processes occurring in allograft and may contribute to a strategy for improvement of graft survival.}, keywords = {*ABO Blood-Group System, Adult, Biopsy, Blood Group Incompatibility / *pathology, Diabetes Mellitus, Type 2 / *complications, Diabetic Nephropathies / *pathology / surgery, Female, Humans, Immunosuppressive Agents / therapeutic use, Kidney Glomerulus / *pathology, Kidney Transplantation / *pathology / physiology, Postoperative Complications / physiopathology, Time Factors}, issn = {0902-0063 (Print) 0902-0063 (Linking)}, author = {Miyagi,M. and Sakai,K. and Hasegawa,A. and Ohara,T. and Mizuiri,S. and Aikawa,A. and Hadano,T. and Nakano,H. and Shindo,M. and Ishikawa,Y. and Hasegawa,C. and Hirayama,N. and Arai,K.} }