@article {973,
	title = {Increasing utilization of human T-cell lymphotropic virus (+) donors in liver transplantation: is it safe?},
	journal = {Transplantation},
	volume = {87},
	year = {2009},
	note = {Marvin, Michael R Brock, Guy N Kwarteng, Kwadwo Nagubandi, Ravi Ravindra, Kadiyala V Eng, Mary Buell, Joseph F P30 ES014443-01A1/ES/NIEHS NIH HHS/ P30ES014443/ES/NIEHS NIH HHS/ Transplantation. 2009 Apr 27;87(8):1180-90.},
	month = {46478},
	pages = {1180 - 90},
	type = {Research Support, N.I.H., Extramural},
	edition = {39926},
	abstract = {BACKGROUND: Liver transplantation is the best treatment option for endstage liver disease. The human T-cell lymphotrophic virus (HTLV) has been associated with leukemia/lymphoma and progressive neurologic disease. There has, however, been an increased utilization of HTLV (+) grafts with little data available to support or discourage their use. METHODS: We performed univariate and multivariate analyses related to graft and patient survival for recipients of HTLV (+) donors and compared them with recipients of HTLV (-) donors using the United Network for Organ Sharing database. Complete analysis of recipient and donor clinical and demographic factors was performed. RESULTS: There were 81 adult recipients of HTLV (+) donors and 29,747 HTLV (-) donor recipients. HTLV (+) donors were more likely to be older, women, and black, with a higher average donor risk index and creatinine, and were more likely to be shared nationally. Recipients of HTLV (+) organs were at slightly elevated risk of graft failure (HR=1.39, 95\% CI 0.91-2.11) and death (HR=1.20, CI 0.71-2.02) relative to HTLV (-) donor recipients (P=0.12 and 0.5, respectively). The risk decreased after multivariate analysis - graft survival (HR=1.20, CI 0.79-1.83) and patient survival (HR=1.06, CI 0.63-1.79). CONCLUSION: Our analysis reveals no statistically significant difference in graft or patient survival between recipients of HTLV (+) and (-) donors. Serious limitations of these data are that serologic testing for HTLV has a high false positive rate and that there was a short follow-up period. Until these issues are addressed, extreme caution should be exercised when using these organs.},
	keywords = {Adult, Aged, Deltaretrovirus Infections / *epidemiology, Ethnic Groups, False Positive Reactions, Female, Graft Survival, Hepatitis Delta Virus, Humans, Liver Transplantation / mortality / *statistics \& numerical data, Male, Middle Aged, Retrospective Studies, Safety, Survival Rate, Survivors / *statistics \& numerical data, Tissue Donors / *statistics \& numerical data, Tumor Virus Infections / epidemiology / mortality},
	issn = {1534-6080 (Electronic) 0041-1337 (Linking)},
	doi = {10.1097/TP.0b013e31819ebf76},
	author = {Marvin,M. R. and Brock,G. N. and Kwarteng,K. and Nagubandi,R. and Ravindra,K. V. and Eng,M. and Buell,J. F.}
}
