@article {961,
	title = {Fatal Epstein-Barr-virus-associated proliferation of donor B cells after treatment of acute graft-versus-host disease with a murine anti-T-cell antibody},
	journal = {Ann Intern Med},
	volume = {101},
	year = {1984},
	note = {Martin, P J Shulman, H M Schubach, W H Hansen, J A Fefer, A Miller, G Thomas, E D CA18029/CA/NCI NIH HHS/United States CA20068/CA/NCI NIH HHS/United States CA29548/CA/NCI NIH HHS/United States etc. Case Reports Research Support, U.S. Gov{\textquoteright}t, P.H.S. United states Annals of internal medicine Ann Intern Med. 1984 Sep;101(3):310-5.},
	month = {Sep},
	pages = {310 - 5},
	edition = {30926},
	abstract = {Two patients with acute leukemia were treated with chemoradiotherapy and allogeneic bone marrow transplantation. Despite the prophylactic use of methotrexate after grafting, both patients developed severe graft-versus-host disease that was refractory to treatment with methylprednisolone. The graft-versus-host disease was then treated with a monoclonal antibody, 64.1, that reacts with a p19 antigen on human T cells. The disease responded dramatically to this treatment, but both patients subsequently developed a fatal polyclonal lymphoproliferative disorder arising in donor-derived B cells. Hybridization studies showed Epstein-Barr virus in both tumors. The combined effect of severe end-stage graft-versus-host disease and potent immunosuppressive therapy probably resulted in a progressive immunodeficiency syndrome that abrogated the T-cell-mediated surveillance mechanism that normally modulates the proliferation of Epstein-Barr-virus-infected B lymphocytes.},
	keywords = {Adult, Animals, Antibodies, Monoclonal / *adverse effects, B-Lymphocytes / *pathology, Bone Marrow Transplantation, Child, Preschool, DNA, Viral / analysis, Female, Graft vs Host Disease / *therapy, Herpesvirus 4, Human / analysis, Humans, Leukemia, Myeloid, Acute / therapy, Lymphoproliferative Disorders / *etiology / pathology, Male, Mice, T-Lymphocytes / *immunology, Tumor Virus Infections / *etiology / pathology},
	issn = {0003-4819 (Print) 0003-4819 (Linking)},
	author = {Martin,P. J. and Shulman,H. M. and Schubach,W. H. and Hansen,J. A. and Fefer,A. and Miller,G. and Thomas,E. D.}
}
