@article {940,
	title = {Creutzfeldt-Jakob disease in recipients of corneal transplants},
	journal = {Cornea},
	volume = {27},
	year = {2008},
	note = {Maddox, Ryan A Belay, Ermias D Curns, Aaron T Zou, Wen-Quan Nowicki, Scott Lembach, Richard G Geschwind, Michael D Haman, Aissa Shinozaki, Naoshi Nakamura, Yosikazu Borer, Mark J Schonberger, Lawrence B AG021601/AG/NIA NIH HHS/United States K23 AG021989/AG/NIA NIH HHS/United States M01 RR00079/RR/NCRR NIH HHS/United States N01 NS02328/NS/NINDS NIH HHS/United States Case Reports Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov{\textquoteright}t United States Cornea Cornea. 2008 Aug;27(7):851-4.},
	month = {Aug},
	pages = {851 - 4},
	edition = {39654},
	abstract = {PURPOSE: Creutzfeldt-Jakob disease (CJD) transmission has been documented to occur from the use of corneal grafts. We report 4 cases of CJD with a history of corneal transplantation and assess the frequency of coincidental CJD among corneal transplant recipients. METHODS: Medical records and eye bank documents were reviewed. Genetic and neuropathologic tests on available specimens were performed at the National Prion Disease Pathology Surveillance Center. Statistical analyses were used to determine the expected number of coincidental CJD cases among the US population with a history of corneal transplantation. RESULTS: Four CJD decedents with histories of corneal transplantation were identified: 3 from the United States and 1 from Japan. The time from transplant to onset of CJD symptoms ranged from 2 years, 11 months to 18 years. Available eye bank records did not suggest evidence of neurologic illness in the donors. Using corneal transplantation and CJD death data from 1990 through 2006, statistical analyses suggest that a case of coincidental sporadic CJD will occur among the population of corneal transplant recipients approximately every 1.5 years. CONCLUSIONS: It is likely that these 4 recipients of transplanted corneas had sporadic CJD. Because of the many corneal transplantations performed each year in the United States, occasional cases of sporadic CJD in this population are expected.},
	keywords = {*Disease Transmission, Infectious, Aged, Corneal Transplantation / *adverse effects, Creutzfeldt-Jakob Syndrome / *transmission, Eye Banks / statistics \& numerical data, Fatal Outcome, Female, Humans, Male, Middle Aged, Tissue Donors},
	issn = {1536-4798 (Electronic) 0277-3740 (Linking)},
	doi = {10.1097/ICO.0b013e31816a628d 00003226-200808000-00021 [pii]},
	url = {internal-pdf://Maddox - CJD-2554209793/Maddox - CJD.pdf},
	author = {Maddox,R. A. and Belay,E. D. and Curns,A. T. and Zou,W. Q. and Nowicki,S. and Lembach,R. G. and Geschwind,M. D. and Haman,A. and Shinozaki,N. and Nakamura,Y. and Borer,M. J. and Schonberger,L. B.}
}
